Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery.
TL;DR: The state of the art of crosslinked ionic polysaccharides as components of delivery systems that can regulate drug release as a function of changes in pH, ion nature and concentration, electric and magnetic field intensity, light wavelength, temperature, redox potential, and certain molecules are analyzed.
About: This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01. It has received 418 citations till now. The article focuses on the topics: Drug delivery.
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TL;DR: A review of recent literature reports on the synthesis and applications of pH-responsive polymers can be found in this article, where the authors provide an analysis of some of the recent literature reported on the synthesizing and applications.
697 citations
TL;DR: The main goal of this paper was to review the sources, natively biological activities, isolation, characterization, and the structural features of natively bioactive polysaccharides from wood species to maximally exploit their various valuable properties in previously unperceived applications.
463 citations
TL;DR: A critical overview of therapeutically-interesting stimuli to trigger drug release and the evolution of responsive materials suitable as functional excipients is offered, illustrated with recent examples of formulations in clinical trials or already commercially available, which can provide a perspective on the current state of the art on smart drug delivery systems.
311 citations
TL;DR: A series of injectable conductive hydrogels based on chitosan-graft-polyaniline (CP) copolymer and oxidized dextran (OD) with "smart" delivery vehicles with electro-responsiveness and pH-responsive properties for triggered and localized release of drugs are designed.
299 citations
TL;DR: This review gives an overview of relevant properties of alginate as oral colon delivery systems and the recent innovative strategies of usingAlginate with other polymers as well as microencapsulation techniques and describes the several advantages of coating processes involving alginates over microparticles in order to design better material with sustained release characteristic for colon-targeted delivery.
294 citations
References
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TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
5,372 citations
"Crosslinked ionic polysaccharides f..." refers background in this paper
...The ratio and the distribution of the M and G blocks notably affect to the sensitiveness of alginate to pH and calcium ions because the different relative position of the carboxylic acid group in each block [34]....
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TL;DR: Global plastics production and the accumulation of plastic waste are documented, showing that trends in mega- and macro-plastic accumulation rates are no longer uniformly increasing and that the average size of plastic particles in the environment seems to be decreasing.
Abstract: One of the most ubiquitous and long-lasting recent changes to the surface of our planet is the accumulation and fragmentation of plastics. Within just a few decades since mass production of plastic...
4,044 citations
"Crosslinked ionic polysaccharides f..." refers background in this paper
...monomers) and environment concerns related to the accumulation of non-biodegradable plastics in the soil and the sea have become relevant drawbacks [5]....
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TL;DR: This review presents a critical analysis of covalently and ionically crosslinked chitosan hydrogels and related networks for medical or pharmaceutical applications and discusses with reference to the specific chemical interactions, which dictate gel formation.
1,930 citations
"Crosslinked ionic polysaccharides f..." refers background in this paper
...Condensing agents such as glutaraldehyde, formaldehyde, genipin or oxalic acid, are widely used to prepare covalently crosslinked networks, whereas calcium phosphate, β-glycerophosphate, citrate, or tripolyphosphate render ionically crosslinked hydrogels [27,28,33]....
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TL;DR: In this review, four mechanisms are introduced to prepare polysaccharides-based nanoparticles, that is, covalent crosslinking, ionic crossl linking, polyelectrolyte complex, and the self-assembly of hydrophobically modified poly Saccharides.
1,508 citations
"Crosslinked ionic polysaccharides f..." refers background in this paper
...Polysaccharides can be also classified as non-polyelectrolites and polyelectrolites, which in turn are divided in positively and negatively charged [21]....
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TL;DR: The transmucosal absorption promoting characteristics of chitosan has been exploited especially for nasal and oral delivery of polar drugs to include peptides and proteins and for vaccine delivery.
Abstract: Chitosan has been investigated as an excipient in the pharmaceutical industry, to be used in direct tablet compression, as a tablet disintegrant, for the production of controlled release solid dosage forms or for the improvement of drug dissolution. Chitosan has, compared to traditional excipients, been shown to have superior characteristics and especially flexibility in its use. Furthermore, chitosan has been used for production of controlled release implant systems for delivery of hormones over extended periods of time. Lately, the transmucosal absorption promoting characteristics of chitosan has been exploited especially for nasal and oral delivery of polar drugs to include peptides and proteins and for vaccine delivery. These properties, together with the very safe toxicity profile, makes chitosan an exciting and promising excipient for the pharmaceutical industry for present and future applications.
1,362 citations