Journal ArticleDOI
Crosstalk between lncRNAs and miRNAs in gastrointestinal cancer drug resistance.
Negin Raei,Reza Safaralizadeh,Mohammadali Hesseinpourfeizi,Abbas Yazdanbod,Farhad Pourfarzi,Saeid Latifi-Navid +5 more
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TLDR
In this article, the authors focused on recently known lncRNAs and their relation with miRNAs, and chemotherapeutic drugs, and their modulation in gastrointestinal cancers, and mentioned the future prospective and clinical application of lncRNA as a critical indicator and biomarker in diagnosis, prognosis, staging, grading, and treatment of gastrointestinal cancers.About:
This article is published in Life Sciences.The article was published on 2021-11-01. It has received 13 citations till now. The article focuses on the topics: Gastrointestinal cancer.read more
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Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug Resistance
TL;DR: The role of lncRNAs and their mechanisms in GC drug resistance may provide novel insights for developing strategies for individual diagnosis and therapy, and the potential clinical applications of lNCRNAs as biomarkers and therapeutic targets in GC are discussed.
Journal ArticleDOI
Signaling pathways and therapeutic interventions in gastric cancer
Zi-Ning Lei,Qiu-Xu Teng,Qin Tian,Wei Chen,Yuhao Xie,Kaiming Wu,Qianlin Zeng,Leli Zeng,Yihang Pan,Zhe S Chen,Yulong He +10 more
TL;DR: In this paper , the regulatory roles of signaling pathways in GC potential biomarkers, and therapeutic targets with an emphasis on recent discoveries are discussed, and the development of treatment for GC, particularly the challenges in developing precision medications, are discussed.
Journal ArticleDOI
MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications
Luis Alberto Bravo-Vázquez,Natalia Frías-Reid,Ana Gabriela Ramos-Delgado,Sofía Madeline Osorio-Pérez,Hania Ruth Zlotnik-Chávez,Surajit Pathak,S. Banerjee,Anindya Bandyopadhyay,Asim K. Duttaroy,Sujay Paul +9 more
TL;DR: In this article , the authors discuss recent experimental evidence regarding the clinical implications of miRNAs and lncRNAs in the pathophysiology of pancreatic cancer, their future potential, as well as the challenges that have arisen in this field of study in order to drive forward the design of ncRNA-based diagnostics and therapeutics for PC.
Journal ArticleDOI
Functional roles of lncRN-TUG1 in hepatocellular carcinoma.
Maryam Farzaneh,Majid Ghasemian,Farhoodeh Ghaedrahmati,Jafar Poodineh,Sajad Varmaziar Najafi,Tariq Masoodi,Dedy Kurniawan,Shahab Uddin,Shirin Azizidoost +8 more
TL;DR: In this article , the potential roles of TUG1 in HCC were summarized and targeted for patients with HCC using TUG2 and its downstream genes, which may be a suitable approach for patients suffering from HCC.
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Non-coding RNAs as potential biomarkers in osteosarcoma
TL;DR: This review summarized the application of ncRNA as biomarkers in OS in detail, and discussed the limitation and future improvement of the potential biomarkers.
References
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Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
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Cancer statistics, 2017
TL;DR: The American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival.
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Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a
Kyoko L. Yap,SiDe Li,Ana M. Muñoz-Cabello,Selina Raguz,Lei Zeng,Shiraz Mujtaba,Jesús Gil,Martin J. Walsh,Ming-Ming Zhou +8 more
TL;DR: In this article, the authors found that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANrIL are found at elevated levels in prostate cancer tissues.
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Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene.
Yojiro Kotake,Tadashi Nakagawa,Kyoko Kitagawa,Shohachi Suzuki,Ning Liu,Masatoshi Kitagawa,Yue Xiong +6 more
TL;DR: Results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15INK4B locus, which is bound by SUZ12, a component of polycomb repression complex 2 (PRC2), and is H3K27-trimethylated.
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Correction: Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
Yapeng Ji,Chuanzhen Yang,Zefang Tang,Yongfeng Yang,Yonglu Tian,Hongwei Yao,Xi Zhu,Zemin Zhang,Jiafu Ji,Xiaofeng Zheng +9 more
TL;DR: This corrects the article DOI: 10.1038/ncomms15308 to indicate that the author of the paper is a post-graduate student at the University of Wisconsin-Madison and not a professor.