Journal ArticleDOI
Crystal structure of a hydrated N-glycoprotein linkage region model and its analogue: Hydrogen bonding and π–π stacking driven molecular assembly
Reads0
Chats0
TLDR
X-ray diffraction analysis of a hydrated N-glycoprotein linkage region model, N1-(2-acetamido-2-deoxy-β- d -glucopyranosyl)acetamide (1) and its N1-benzamido analogue 2 reveals very interesting molecular architecture involving seven hydrogen bonds in both compounds and further stabilization of packing in 2 due to π-π stacking as mentioned in this paper.About:
This article is published in Carbohydrate Research.The article was published on 1998-07-01. It has received 22 citations till now. The article focuses on the topics: Stacking & Hydrogen bond.read more
Citations
More filters
Journal ArticleDOI
Structure, conformation, and dynamics of bioactive oligosaccharides: theoretical approaches and experimental validations
Anne Imberty,Serge Pérez +1 more
Journal ArticleDOI
The crystal structure of the 1:1 complex of β-cyclodextrin with trans-cinnamic acid
TL;DR: The crystal structure of the 1:1 complex of beta-cyclodextrin (cyclomaltoheptaose) with trans-cinnamic acid was studied by X-ray diffraction and showed strong hydrogen bonds with two water molecules lying in the interdimeric space of the hydrophobic channel.
Journal ArticleDOI
Observation of a unique pattern of bifurcated hydrogen bonds in the crystal structures of the N-glycoprotein linkage region models.
TL;DR: An analysis of C-H)...O interactions in the crystal structures of all N-glycoprotein linkage region models and analogs reveals a cooperative network of bifurcated hydrogen bonds consisting of N-H...O and C-h...O interactions seen uniquely for the models.
Journal ArticleDOI
Insights into the Geometrical Features Underlying β-O-GlcNAc Glycosylation: Water Pockets Drastically Modulate the Interactions between the Carbohydrate and the Peptide Backbone
Alberto Fernández-Tejada,Francisco Corzana,Jesús H. Busto,Gonzalo Jiménez-Osés,Jesús Jiménez-Barbero,Alberto Avenoza,Jesús M. Peregrina +6 more
TL;DR: The authors suggested the occurrence of two conformations for the O-GlcNAc-Ser glycosidic linkage, each displaying similar occupancy, and this experimental finding clearly suggests a significant degree of mobility for this moiety.
Journal ArticleDOI
On the structural significance of the linkage region constituents of N-glycoproteins: an X-ray crystallographic investigation using models and analogs.
TL;DR: It is speculated that the linkage region constituents of the eukaryotic N-glycoproteins appear to fulfill three essential structural requirements: rigidity, planarity, and linearity and these are met by the trisaccharide core and Asn at the linkage area.