CT and MRI early vessel signs reflect clot composition in acute stroke.
David S Liebeskind,Nerses Sanossian,William H. Yong,Sidney Starkman,Michael Tsang,Antonio L. Moya,David D. Zheng,Anna M. Abolian,Doojin Kim,Latisha K Ali,Samir H. Shah,Amytis Towfighi,Bruce Ovbiagele,Chelsea S. Kidwell,Satoshi Tateshima,Reza Jahan,Gary Duckwiler,Fernando Vinuela,Noriko Salamon,J. Pablo Villablanca,Harry V. Vinters,Victor J. Marder,Jeffrey L. Saver +22 more
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TLDR
CT HMCAS and gradient-echo MRI BA reflect pathology of occlusive thrombus, whereas absence of H MCAS or BA may indicate fibrin-predominant occlusion thrombi.Abstract:
Background and Purpose—The purpose of this study was to provide the first correlative study of the hyperdense middle cerebral artery sign (HMCAS) and gradient-echo MRI blooming artifact (BA) with p...read more
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Journal ArticleDOI
Neutrophil extracellular traps in ischemic stroke thrombi.
Elodie Laridan,Frederik Denorme,Linda Desender,Olivier François,Tommy B. Andersson,Tommy B. Andersson,Hans Deckmyn,Karen Vanhoorelbeke,Simon F. De Meyer +8 more
TL;DR: This study aimed at investigating the presence of neutrophils and more specifically NETs in ischemic stroke thrombi and found that neutrophil extracellular traps promote thrombus formation.
Journal ArticleDOI
Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.
Douglas B. Cines,Tatiana Lebedeva,Chandrasekaran Nagaswami,Vincent Hayes,Walter Massefski,Rustem I. Litvinov,Lubica Rauova,Lubica Rauova,Thomas Jay Lowery,John W. Weisel +9 more
TL;DR: It is found that contracted clots develop a remarkable structure, with a meshwork of fibrin and platelet aggregates on the exterior of the clot and a close-packed, tessellated array of compressed polyhedrocytes within.
Journal ArticleDOI
Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review
Waleed Brinjikji,Sharon Duffy,Anthony M. Burrows,Werner Hacke,David S Liebeskind,Charles B. L. M. Majoie,Diederik W.J. Dippel,Adnan H. Siddiqui,Pooja Khatri,Blaise Baxter,Raul Nogeuira,Matthew J. Gounis,Tudor G Jovin,David F. Kallmes +13 more
TL;DR: The hyperdense artery sign is associated with RBC-rich thrombi and improved recanalization rates, however, there was no association between the histopathological characteristics of thROMbi and stroke etiology and angiographic outcomes.
Journal ArticleDOI
Thrombus Histology Suggests Cardioembolic Cause in Cryptogenic Stroke
Tobias Boeckh-Behrens,Justus F Kleine,Claus Zimmer,Frauke Neff,Fabian Scheipl,Jaroslav Pelisek,Lucas Schirmer,Kim Nguyen,Deniz Karatas,Holger Poppert +9 more
TL;DR: The findings support the notion that the majority of cryptogenic strokes are cardioembolic, and quantitative evaluation of thrombus composition may help to distinguish between different stroke causes.
Journal ArticleDOI
Histopathologic composition of cerebral thrombi of acute stroke patients is correlated with stroke subtype and thrombus attenuation.
Joris M. Niesten,Irene C. van der Schaaf,Lievay van Dam,Aryan Vink,Jan Albert Vos,Wouter J. Schonewille,Peter C. de Bruin,Willem P.Th.M. Mali,Birgitta K. Velthuis +8 more
TL;DR: A correlation between the RBC-component and thrombus attenuation is found, which improves validation of throm Bus attenuation on NCCT as an imaging biomarker for stroke management.
References
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Journal ArticleDOI
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
James C. Grotta,M Kothari,K.M.A. Welch,Joseph P. Broderick,Barbara C. Tilley,Thomas G. Brott,Marler,Patrick D. Lyden,Paul M. O'Byrne +8 more
Journal ArticleDOI
Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke
Randall T. Higashida,Anthony J. Furlan,Heidi C. Roberts,Thomas Tomsick,Buddy Connors,John D. Barr,William P. Dillon,Steven Warach,Joseph P. Broderick,Barbara C. Tilley,David Sacks +10 more
TL;DR: This document serves to standardize reporting terminology and includes pretreatment assessment, neurologic evaluation with the NIH Stroke Scale score, imaging evaluation, occlusion sites, perfusion grades, follow-up imaging studies, and neurologic assessments, and suggestions for uniform reporting standards for such trials.
Journal ArticleDOI
Mechanical Thrombectomy for Acute Ischemic Stroke: Final Results of the Multi MERCI Trial
Wade S. Smith,Gene Sung,Jeffrey L. Saver,Ronald F. Budzik,Gary Duckwiler,David S Liebeskind,Helmi L. Lutsep,Marilyn M. Rymer,Randall T. Higashida,Sidney Starkman,Y. Pierre Gobin +10 more
TL;DR: Higher rates of recanalization were associated with a newer generation thrombectomy device compared with first-generation devices, but these differences did not achieve statistical significance.
Journal ArticleDOI
The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease.
TL;DR: The results suggest the Penumbra System allows safe and effective revascularization in patients experiencing ischemic stroke secondary to large vessel occlusive disease who present within 8 hours from symptom onset.
Journal Article
Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk.
R. von Kummer,Uta Meyding-Lamadé,Michael Forsting,Ludger Rosin,Klaus Rieke,Werner Hacke,Klaus Sartor +6 more
TL;DR: Early CT in acute middle cerebral artery trunk occlusion is highly predictive for fatal clinical outcome if there is extended hypodensity or local brain swelling despite aggressive therapeutic attempts such as thrombolysis or decompressive surgery.
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