Journal ArticleDOI
Curative cerebrovascular reconstruction with the Pipeline embolization device: the emergence of definitive endovascular therapy for intracranial aneurysms
David Fiorella,Pedro Lylyk,István Szikora,Michael Kelly,Felipe C. Albuquerque,Cameron G. McDougall,Peter Kim Nelson +6 more
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TLDR
The Pipeline embolization device (PED; Chestnut Medical) represents a new generation endoluminal implant which is designed to treat aneurysms by reconstructing the diseased parent artery.Abstract:
Endovascular, endosaccular, coil embolization has emerged as an established therapy for both ruptured and unruptured cerebral aneurysms. However, many aneurysms are not cured using conventional endovascular techniques. Coil embolization often results in incomplete aneurysm occlusion or recanalization in the ensuing months after treatment. The Pipeline embolization device (PED; Chestnut Medical) represents a new generation endoluminal implant which is designed to treat aneurysms by reconstructing the diseased parent artery. Immediately after implantation, the PED functions to divert flow from the aneurysm, creating an environment conducive to thrombosis. With time, the PED is incorporated into the vessel wall as neointimal-endothelial overgrowth occurs along the construct. Ultimately, this process results in the durable complete exclusion of the aneurysm from the cerebrovasculature and a definitive endoluminal reconstruction of the diseased parent artery.read more
Citations
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Journal ArticleDOI
The Pipeline Embolization Device for the Intracranial Treatment of Aneurysms Trial
TL;DR: Intracranial aneurysm treatment with the PED is technically feasible and can be achieved with a safety profile analogous to that reported for stent-supported coil embolization, as presented in the first prospective multicenter trial of a flow-diverting construct for the treatment of intracranialAneurysms.
Journal ArticleDOI
Early experience in the treatment of intra-cranial aneurysms by endovascular flow diversion: a multicentre prospective study.
TL;DR: Delayed morbidity appears to be a consequence of the new approach and warrants care in selecting patients for treatment and future larger studies, and anti-thrombosis prophylaxis appears to reduce the resulting clinical sequelae, but at the cost of morbidity due to extracranial bleeding.
Journal ArticleDOI
Italian multicenter experience with flow-diverter devices for intracranial unruptured aneurysm treatment with periprocedural complications—a retrospective data analysis
Francesco Briganti,M. Napoli,Fabio Tortora,Domenico Solari,Mauro Bergui,Edoardo Boccardi,Enrico Cagliari,Lucio Castellan,Francesco Causin,Elisa Ciceri,Luigi Cirillo,Roberto De Blasi,Luigi Delehaye,Francesco Di Paola,Andrea Fontana,Roberto Gasparotti,Giulio Guidetti,Ignazio Divenuto,Giuseppe Iannucci,Maurizio Isalberti,Marco Leonardi,Fernando Lupo,Salvatore Mangiafico,Andrea Manto,Roberto Menozzi,Mario Muto,Nunzio Paolo Nuzzi,Rosario Papa,Benedetto Petralia,Mariangela Piano,Maurizio Resta,Riccardo Padolecchia,Andrea Saletti,Giovanni Sirabella,Luca Piero Valvassori Bolgè +34 more
TL;DR: A retrospective study confirms that morbidity and mortality rates in treatment with FDD of unruptured wide-neck or untreatable cerebral aneurysms do not differ from those reported in the largest series.
Journal ArticleDOI
Very Late Thrombosis of a Pipeline Embolization Device Construct: Case Report
TL;DR: The very late (>1 year) thrombosis of a PED construct placed for the treatment of a left vertebral aneurysm is reported, highlighting the need for a continued, careful systematic evaluation and close long-term follow-up of treated patients.
Journal ArticleDOI
The Woven EndoBridge: a new aneurysm occlusion device.
TL;DR: The WEB device in experimental aneurysms demonstrated promising rates of immediate and long-termAneurysm occlusion, and its acute and chronic performance regarding immediacy, degree, and durability was evaluated.
References
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Journal ArticleDOI
International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms : a randomised trial
TL;DR: In patients with a ruptured intracranial aneurysm, for which endov vascular coiling and neurosurgical clipping are therapeutic options, the outcome in terms of survival free of disability at 1 year is significantly better with endovascular coiling.
Journal ArticleDOI
International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion
Andrew J. Molyneux,Richard S. C. Kerr,Ly-Mee Yu,Mike Clarke,Mary Sneade,Julia A. Yarnold,Peter Sandercock +6 more
TL;DR: In patients with ruptured intracranial aneurysms suitable for both treatments, endovascular coiling is more likely to result in independent survival at 1 year than neurosurgical clipping; the survival benefit continues for at least 7 years.
Journal ArticleDOI
Long-Term Angiographic Recurrences After Selective Endovascular Treatment of Aneurysms With Detachable Coils
Jean Raymond,François Guilbert,Alain Weill,Stavros A. Georganos,Louis Juravsky,Anick Lambert,Julie Lamoureux,Miguel Chagnon,Daniel Roy +8 more
TL;DR: Variables determined to be significant predictors of a recurrence included aneurysm size ≥10 mm, treatment during the acute phase of rupture, incomplete initial occlusions, and duration of follow-up, and long-term monitoring of patients treated by endosaccular coiling is mandatory.
Journal ArticleDOI
International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial.
Andrew J. Molyneux,Richard S. C. Kerr,Irene M Stratton,Peter Sandercock,Mike Clarke,Julia A Shrimpton,Rury R. Holman +6 more
TL;DR: In patients with a ruptured intracranial aneurysm, for which endovascular coiling and neurosurgical clipping are therapeutic options, the outcome in terms of survival free of disability at 1 year is significantly better with endov vascular coiling.
Journal ArticleDOI
Guglielmi Detachable Coil embolization of cerebral aneurysms: 11 years' experience
Yuichi Murayama,Yih Lin Nien,Gary Duckwiler,Y. Pierre Gobin,Reza Jahan,John G. Frazee,Neil A. Martin,Fernando Vinuela +7 more
TL;DR: The clinical and postembolization outcomes in patients treated with the GDC system have improved in the past 5 years, and aneurysm recanalization is still a major limitation of current GDC therapy.
Related Papers (5)
Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial.
Tibor Becske,David F. Kallmes,Isil Saatci,Cameron G. McDougall,István Szikora,Giuseppe Lanzino,Christopher J. Moran,Henry H. Woo,Demetrius K. Lopes,Aaron L. Berez,Daniel J. Cher,Adnan H. Siddiqui,Elad I. Levy,Felipe C. Albuquerque,David Fiorella,Zsolt Berentei,Miklos G. Marosfoi,Saruhan Cekirge,Peter Kim Nelson +18 more