Curcumin and cancer: An “old-age” disease with an “age-old” solution

doi:10.1016/J.CANLET.2008.03.025

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Curcumin and cancer: An “old-age” disease with an “age-old” solution

Journal Article•DOI•

Curcumin and cancer: An “old-age” disease with an “age-old” solution

Preetha Anand¹, Chitra Sundaram¹, Sonia Jhurani¹, Ajaikumar B. Kunnumakkara¹, Bharat B. Aggarwal - Show less +1 more•Institutions (1)

University of Texas MD Anderson Cancer Center¹

18 Aug 2008-Cancer Letters (Elsevier)-Vol. 267, Iss: 1, pp 133-164

TL;DR: The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets.

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About: This article is published in Cancer Letters.The article was published on 2008-08-18. It has received 1014 citations till now. The article focuses on the topics: Cancer & Metastasis.

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Journal Article•DOI•

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

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Preetha Anand¹, Ajaikumar B. Kunnumakara¹, Chitra Sundaram¹, Kuzhuvelil B. Harikumar¹, Sheeja T. Tharakan¹, Oiki S. Lai¹, Bokyung Sung¹, Bharat B. Aggarwal¹ - Show less +4 more•Institutions (1)

University of Texas MD Anderson Cancer Center¹

15 Jul 2008-Pharmaceutical Research

TL;DR: Evidence that inflammation is the link between the agents/factors that cause cancer and the agents that prevent it is presented and evidence that cancer is a preventable disease that requires major lifestyle changes is provided.

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Abstract: This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle. The lifestyle factors include cigarette smoking, diet (fried foods, red meat), alcohol, sun exposure, environmental pollutants, infections, stress, obesity, and physical inactivity. The evidence indicates that of all cancer-related deaths, almost 25–30% are due to tobacco, as many as 30–35% are linked to diet, about 15–20% are due to infections, and the remaining percentage are due to other factors like radiation, stress, physical activity, environmental pollutants etc. Therefore, cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups. In this review, we present evidence that inflammation is the link between the agents/factors that cause cancer and the agents that prevent it. In addition, we provide evidence that cancer is a preventable disease that requires major lifestyle changes.

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1,915 citations

Cites background from "Curcumin and cancer: An “old-age” d..."

...A detailed description of curcumin and its anticancer properties can be found in one of our recent reviews (79)....
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Journal Article•DOI•

Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases

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Bharat B. Aggarwal¹, Kuzhuvelil B. Harikumar¹•Institutions (1)

University of Texas MD Anderson Cancer Center¹

01 Jan 2009-The International Journal of Biochemistry & Cell Biology

TL;DR: Evidence for the potential role of curcumin in the prevention and treatment of various proinflammatory chronic diseases is provided and its features, combined with the pharmacological safety and negligible cost, renderCurcumin an attractive agent to explore further.

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1,542 citations

Cites background from "Curcumin and cancer: An “old-age” d..."

...…well as in vivo studies demonstrated that curcumin can inhibit the growth of various cancer cells from different organs including blood, brain, breast, gastrointestinal system, head and neck, liver, pancreas, colon, prostate, ovary and skin cancers (Anand et al., 2008) (Kunnumakkara et al., 2008)....
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Journal Article•DOI•

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

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Dongmei Sun¹, Xiaoying Zhuang¹, Xiaoying Zhuang², Xiaoyu Xiang¹, Xiaoyu Xiang², Yuelong Liu¹, Shuangyin Zhang¹, Cunren Liu¹, Stephen Barnes¹, William E. Grizzle¹, Donald R. Miller², Huang-Ge Zhang - Show less +8 more•Institutions (2)

University of Alabama at Birmingham¹, University of Louisville²

01 Sep 2010-Molecular Therapy

TL;DR: It is reported that exosomes can deliver anti-inflammatory agents, such as curcumin, to activated myeloid cells in vivo, and the therapeutic relevance of this technique is validated in a lipopolysaccharide (LPS)-induced septic shock mouse model.

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1,203 citations

Journal Article•DOI•

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.

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Preetha Anand¹, Sherin G. Thomas², Ajaikumar B. Kunnumakkara, Chitra Sundaram, Kuzhuvelil B. Harikumar, Bokyung Sung, Sheeja T. Tharakan, Krishna Misra³, Indira K. Priyadarsini⁴, Kallikat N. Rajasekharan², Bharat B. Aggarwal - Show less +7 more•Institutions (4)

University of Texas MD Anderson Cancer Center¹, University of Kerala², Indian Institute of Information Technology, Allahabad³, Bhabha Atomic Research Centre⁴

01 Dec 2008-Biochemical Pharmacology

TL;DR: This review focuses on the status of all these approaches in generating a "super curcumin," a homodimer of feruloylmethane containing a methoxy group and a hydroxyl group, a heptadiene with two Michael acceptors, and an alpha,beta-diketone.

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1,095 citations

Cites background from "Curcumin and cancer: An “old-age” d..."

...[11] Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB....
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Journal Article•DOI•

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

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Dinh Ha¹, Ningning Yang¹, Venkatareddy Nadithe¹•Institutions (1)

University of Manchester¹

01 Jul 2016-Acta Pharmaceutica Sinica B

TL;DR: The origin and structure of exosomes as well as their biological functions are outlined and specific applications of exOSomes as drug delivery systems in pharmaceutical drug development are focused on.

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891 citations

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References

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Journal Article•DOI•

Cancer statistics, 2007.

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Ahmedin Jemal¹, Rebecca L. Siegel², Elizabeth Ward¹, Taylor Murray¹, Jiaquan Xu³, Michael J. Thun¹ - Show less +2 more•Institutions (3)

American Cancer Society¹, Hong Kong Information Services Department², Centers for Disease Control and Prevention³

01 Jan 2007-CA: A Cancer Journal for Clinicians

TL;DR: While the absolute number of cancer deaths decreased for the second consecutive year in the United States, much progress has been made in reducing mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years.

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Abstract: Each year, the American Cancer Society (ACS) estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics This report considers incidence data through 2003 and mortality data through 2004 Incidence and death rates are age-standardized to the 2000 US standard million population A total of 1,444,920 new cancer cases and 559,650 deaths for cancers are projected to occur in the United States in 2007 Notable trends in cancer incidence and mortality rates include stabilization of the age-standardized, delay-adjusted incidence rates for all cancers combined in men from 1995 through 2003; a continuing increase in the incidence rate by 03% per year in women; and a 136% total decrease in age-standardized cancer death rates among men and women combined between 1991 and 2004 This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends While the absolute number of cancer deaths decreased for the second consecutive year in the United States (by more than 3,000 from 2003 to 2004) and much progress has been made in reducing mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population

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7,446 citations

Journal Article•DOI•

Bioavailability of curcumin: problems and promises.

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Preetha Anand¹, Ajaikumar B. Kunnumakkara¹, Robert A. Newman¹, Bharat B. Aggarwal•Institutions (1)

University of Texas MD Anderson Cancer Center¹

14 Nov 2007-Molecular Pharmaceutics

TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.

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Abstract: Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Phase I clinical trials have shown that curcumin is safe even at high doses (12 g/day) in humans but exhibit poor bioavailability. Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipid complex; and fifth, the use of structural analogues of curcumin (e.g., EF-24). The latter has been reported to have a rapid absorption with a peak plasma half-life. Despite the lower bioavailability, therapeutic efficacy of...

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4,275 citations

"Curcumin and cancer: An “old-age” d..." refers background in this paper

...A polymeric nanocurcumin formulation also demonstrated a therapeutic efficacy comparable to that of free curcumin in a panel of human pancreatic cancer cell lines in vitro, and the mechanisms of action of nanocurcumin in pancreatic cancer cells mirrored those of free curcumin[54]....
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Journal Article•DOI•

Mild cognitive impairment

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Serge Gauthier¹, Barry Reisberg², Michael Zaudig, Ronald C. Petersen³, Karen Ritchie⁴, Karl Broich⁵, Sylvie Belleville, Henry Brodaty⁶, David A. Bennett⁷, Howard Chertkow¹, Jeffrey L. Cummings⁸, Mony J. de Leon², Howard Feldman⁹, Mary Ganguli¹⁰, Harald Hampel¹¹, Philip Scheltens¹², Mary C. Tierney¹³, Peter J. Whitehouse¹⁴, Bengt Winblad¹⁵ - Show less +15 more•Institutions (15)

McGill University¹, New York University², Mayo Clinic³, French Institute of Health and Medical Research⁴, Federal Institute for Drugs and Medical Devices⁵, University of New South Wales⁶, Rush University Medical Center⁷, University of California, Los Angeles⁸, Vancouver Hospital and Health Sciences Centre⁹, University of Pittsburgh¹⁰, Ludwig Maximilian University of Munich¹¹, VU University Medical Center¹², Women's College, Kolkata¹³, Case Western Reserve University¹⁴, Karolinska Institutet¹⁵

15 Apr 2006-The Lancet

TL;DR: Mild cognitive impairment can be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension.

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3,962 citations

Journal Article•

Anticancer potential of curcumin: preclinical and clinical studies.

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Bharat B. Aggarwal¹, Anushree Kumar¹, Alok C. Bharti¹•Institutions (1)

University of Texas MD Anderson Cancer Center¹

01 Jan 2003-Anticancer Research

TL;DR: Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.

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Abstract: Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors NF- κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies. Curcumin, derived from turmeric (vernacular name: Haldi), is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda (the Indian

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2,453 citations

"Curcumin and cancer: An “old-age” d..." refers background in this paper

...Although the growth of tumors at the implanted site was not affected by the curcumin treatment there was a significant and dose dependant decrease in number of intrahepatic metastases [43]....
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...Curcumin is a diferuloylmethane derived from the Indian spice, turmeric (popularly called ‘‘curry powder”) that has been shown to interfere with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of antiapoptotic gene products), proliferation (HER-2, EGFR, and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-jB, TNF, IL-6, IL-1, COX-2, and 5-LOX)....
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...The antiangiogenic activity of curcumin in hepatocarcinoma cells implanted in nude mice was found to be mediated through the reduction of biomarkers COX-2 and VEGF [43]....
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...Treatment with liposomal curcumin resulted in reduced tumor size and visible blanching of tumors showing decreased expression of CD31 as well as VEGF and IL-8....
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...7% increase in the curcumin only group [7,43]....
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Journal Article•DOI•

Curcumin as “Curecumin”: From kitchen to clinic

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Ajay Goel¹, Ajaikumar B. Kunnumakkara², Bharat B. Aggarwal•Institutions (2)

Baylor University Medical Center¹, University of Texas MD Anderson Cancer Center²

15 Feb 2008-Biochemical Pharmacology

TL;DR: Curcumin, a spice once relegated to the kitchen shelf, has moved into the clinic and may prove to be "Curecumin", a therapeutic agent in wound healing, diabetes, Alzheimer disease, Parkinson disease, cardiovascular disease, pulmonary disease, and arthritis.

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1,897 citations

"Curcumin and cancer: An “old-age” d..." refers background in this paper

...Treatment with liposomal curcumin resulted in reduced tumor size and visible blanching of tumors showing decreased expression of CD31 as well as VEGF and IL-8....
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...In one, dietary curcumin (500 ppm) fed during initiation and post-initiation stages inhibited the incidence of oesophageal carcinogenesis by 27% and 33%, respectively, in rats [2]....
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...There was no corresponding improvement in pain [2]....
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...One of our recently published reviews presents a more detailed description of the molecular targets of curcumin [2]....
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...In the control group only 17% animals were having few metastatic nodules (metastatic score <3) whereas in curcumin-treated group 68% animals had few metastatic nodules [2]....
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