Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function.
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700 citations
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...The direct inhibition of proteasome activity also causes an increase in half-life of IκBα that ultimately leads to the down-regulation of NF-κB activation (169), thus activating the apoptotic pathway....
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...Studies have shown that curcumin mediates its apoptotic and antiinflammatory activities through modulation of the redox status of the cell (42,149,169)....
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447 citations
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...Other phenolic compounds with similar activity, a negative effect on cancer cells’ proteasome, are catechin-3-gallate and epigallocatechin gallate [223,224], gallic acid [225] apigenin, quercetin and myricetin [226], curcumin [227], and genistein [228]....
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387 citations
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...The curcumin-induced proteasomal malfunction might e linked with both antiproliferative and antiinflammatory activities.(80) NF- B plays important roles in inflammation, cell proliferation, apotosis, and oncogenesis....
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374 citations
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...Curcumin inhibits the Notch signaling pathway in pancreatic cancer cells [69], and has been shown to be a potent proteasomal inhibitor [70], inhibiting the 20S proteasome and inducing degradation of IκBα in colon cancers [71]....
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213 citations
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...In their follow-up studies, these authors demonstrated that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome's 20S core catalytic component [136, 137]....
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...The direct inhibition of proteasome activity also caused an increase in the half-life of IjB-alpha that ultimately led to the down-regulation of NF-jB activation [136]....
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References
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