Journal ArticleDOI
Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function.
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TLDR
It is shown that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome’s 20S core catalytic component, which causes an increase in half-life of IκB-α that ultimately leads to the down-regulation of NF-κB activation.Abstract:
Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin proteasome system (UPS). Here, we show that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome's 20S core catalytic component. Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153. The direct inhibition of proteasome activity also causes an increase in half-life of IkappaB-alpha that ultimately leads to the down-regulation of NF-kappaB activation. These results suggest that curcumin-induced proteasomal malfunction might be linked with both anti-proliferative and anti-inflammatory activities.read more
Citations
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Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
TL;DR: Curcumin modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway, cell survival pathway, and protein kinase pathway.
Journal ArticleDOI
The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders
Magdalena Działo,Justyna Mierziak,Urszula Korzun,Marta Preisner,Jan Szopa,Jan Szopa,Anna Kulma +6 more
TL;DR: This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.
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Role of curcumin in cancer therapy
TL;DR: Curcumin has been shown to have protective and therapeutic effects against cancers of the blood, skin, oral cavity, lung, pancreas, and intestinal tract, and to suppress angiogenesis and metastasis in rodents.
Journal ArticleDOI
The Multifaceted Role of Curcumin in Cancer Prevention and Treatment
Muthu K. Shanmugam,Grishma Rane,Madhu Mathi Kanchi,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Benny K. H. Tan,Alan Prem Kumar,Gautam Sethi,Gautam Sethi,Gautam Sethi +11 more
TL;DR: The current review focuses on the diverse molecular targets modulated by curcumin that contribute to its efficacy against various human cancers.
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Multi-targeted therapy by curcumin: how spicy is it?
TL;DR: Curcumin regulates multiple targets (multitargeted therapy), which is needed for treatment of most diseases, and it is inexpensive and has been found to be safe in human clinical trials.
References
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Journal ArticleDOI
Pharmacophore Model for Novel Inhibitors of Ubiquitin Isopeptidases That Induce p53-Independent Cell Death
J. E. Mullally,F. A. Fitzpatrick +1 more
TL;DR: Using the National Cancer Institute's Developmental Therapeutics Database to identify compounds to test the pharmacophore and mechanism of action hypothesis, data verify the p53-independence of cell death caused by inhibitors of the proteasome pathway and support the proposition that the ubiquitin-dependent proteasom pathway may contain molecular targets suitable for antineoplastic drug discovery.
Journal ArticleDOI
Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells.
TL;DR: The results suggest that the SAPK signal transduction cascade may be an alternative and/or parallel pathway in the regulation of neuronal differentiation.
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