Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
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Cites background from "Curcumin Inhibits Formation of Amyl..."
...[51] Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, et al....
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...Despite preclinical evidence of curcumin’s ability to bind bamyloids and thereby reduce plaque burdens [51], there has been little, if any, supporting epidemiologic evidence of this....
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...By directly binding small b-amyloid species, curcumin blocks aggregation and fibril formation in vitro and in vivo [51]....
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1,542 citations
Cites background from "Curcumin Inhibits Formation of Amyl..."
...Yang et al (Yang et al., 2005) showed that curcumin could inhibit aggregated as well as disaggregated fAbeta40....
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...…damage and oxidative pathology Lim et al, 2001 Tg mice 500 ppm, diet, 50μM, i.v Inhibits A beta oligomers & fibrils, binds plaques and reduces amyloid1 Yang et al, 2005 Mice 7.5, i.v Clears and reduces existing plaques; reversed changes in dystrophic dendrities, abnormal curvature and…...
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...Kim et al, 2001 In vitro 0.1–1μM Inhibits A beta fibril formation Ono et al, 2004 In vitro Curcumin interacts with Cu and Fe Baum et al, 2004 In vitro 0.1–10μM Inhibits the peroxidase activity of A beta-heme complex Atamna et al, 2006 In vitro 0.1μM Enhances uptake of A beta by macrophages from AD Zhang et al, 2006 In vitro 0.1μM Enhances Abeta uptake by increasing exp of MGAT3 and TLRs Fiala et al, 2007 Tg mice 160, 5000 ppm, diet Reduces oxidative damage and oxidative pathology Lim et al, 2001 Tg mice 500 ppm, diet, 50μM, i.v Inhibits A beta oligomers & fibrils, binds plaques and reduces amyloid1 Yang et al, 2005 Mice 7.5, i.v Clears and reduces existing plaques; reversed changes in dystrophic dendrities, abnormal curvature and dystrophy size Garcia-Alloza et al, 2007 Patients Capsule or diet No side effects, increased the level of A beta in serum Baum et al, 2008 Multiple sclerosis: In vitro Modulates IFN-β and IL-12 signaling Fahey et al, 2007 Mice 50,100μg, i.p Decreased EAE and IL-12 production, Inhibited IL-12 induced JAK2 and TYK2 phosphorylation Natarajan et al, 2002 Mice 2.5 mg/mL, d.w Delays recovery from EAE Verbeek et al, 2005 Parkinson Disease: In vitro 50μM Reverses peroxynitrate mediated inhibition brain mitochondria complex I Mythri et al, 2007 Rats 50mg/kg, p.o Attenuated the loss of dopaminergic neurons, protects rats from 6-OHDA induced Parkinson disease Zbarsky et al, 2005 Epilepsy: Mice 3,30 mg/kg, i.p Decrease the severity of epilepsy, attenuated kainate induced histone modifications Sng et al, 2006 Rats 50 mg/kg, i.p Protects from KA induced neuronal damage, reduced the level of NO, decrease the expression of c-jun, COX-2, BDNF, and iNOS2 Sumanont et al, 2006, 2007 Cerebral injury: Rat 50,100,200 mg/kg, ip Protects rat brain against I/R injury through modulation of XO, O2−, MDA, GPx SOD and LDH Ghoneim et al, 2002 Rats 100, 300, mg/kg, ip Protects rat brain from cerebral ischemia, modulate the activity of GPx, and SOD Thiyagarajan et al, 2004 Mangolian 30 mg/kg, ip or Protects I/R-induced neuronal cell death and glial activation; decreased LPO Wang, et al, 2005 Gerbils 2 g/kg, diet mitochondrial dysfunction and the apoptosis; curcumin levels goes up in plasma and brain within 1h Rats 200mg/kg, i.p Reduced the neuronal damage, decreased the level of LPO, increased the level of GSH and activities of SOD and CAT Al-Omar et al, 2006 Int J Biochem Cell Biol....
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...N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Disease Dose Effects References Rats 500mg/kg, i.p Delayed neuronal death, increase antioxidant system and levels of peroxynitrite3 Rathore et al, 2008 Rats 1,2 mg/kg, i.v Prevent blood-brain barrier damage, improved neurological deficit, decreased mortality and the level of iNOS, Jiang et al, 2008 Cardiovascular diseases: In vitro 10 μmol/L Inhibits high glucose-induced foam cell formation by inhibition of NF-κB Li et al, 2004 In vitro 1–25 uM Inhibited PDGF-induced migration, proliferation and collagen synthesis in cultured VSMCs Yang et al, 2006 In vitro 10μM Inhibited CRP-induced PAI-1 mRNA expression in HCAEC Chen et al, 2007 In vitro 100μg Improved blood compatibility of rapamycin-eluting stent Pan et al, 2007 Mice 25–100 mg/kg, i.p Antithrombotic effects Srivastava et al, 1985 Rats 200 mg/kg, p.o Prevents isoproterenol-induced myocardial infaraction Nirmala et al, 1996 a&b Rats 200 mg/kg, po Protects from adriamycin-induced myocardial toxicity Venkatesan et al, 1998 Rabbits 1.6,3.2 mg/kg, p.o Decreases the LPO of liver microsomes and mitochondria4 Quiles et al, 1998 Rabbits 1.6,3.2 mg/kg, p.o Inhibits LDL oxidation & has hyocholesteromic effects4 Ramirez-Tortosa et al, 1999 Rabbits 1.6 mg/kg, p.o Reduces oxidative stresss and reduces aortic fatty streak4 Quiles et al, 2002 Rats 15 mg/kg, p.o Decreases the levels of O2−, XO, MPO....
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...MCP-1, MMP-9 in aortic tissue; inhibits Parodi et al, 2006 Rats 72 μg in gel Inhibit VSMC function; attenuated carotid artery neointima formation destructive connective tissue remodeling in experimental AAAs Yang et al, 2006 Mice 75 mg/kg, p.o Blocked phenylephrin (PE)-induced cardiac hypertrophy, prevented and reversed mouse cardiac hypertrophy induced by AB and PE infusion, abrogated histone acetylation, GATA4 acetylation, and DNA-binding by blocking p300-HAT Li et al, 2008 Rats 50 mg/kg, p.o Inhibited the hypertrophy-induced acetylation and DNA-binding abilities of GATA4, disrupted the p300/GATA4 complex and repressed hypertrophic responses....
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1,526 citations
Cites background from "Curcumin Inhibits Formation of Amyl..."
...It is suggested that dietary supplementation with curcumin may be beneficial in neurodegenerative diseases such as Alzheimer's disease (Calabrese et al., 2003; Yang et al., 2005)....
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References
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