Journal ArticleDOI
Current Developments of Coumarin Compounds in Medicinal Chemistry
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TLDR
The whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains are presented.Abstract:
Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This type of special benzopyrone structure enables its derivatives readily interact with a diversity of enzymes and receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, some coumarin-based drugs such as anticoagulant and antineurodegenerative agents have been extensively used in clinic. Coumarin-containing supramolecular medicinal agents as a new increasing expansion of supramolecular chemistry in pharmaceutical science have also been actively investigated in recent years. Coumarin-derived artificial ion receptors, fluorescent probes and biological stains are growing quickly and have a variety of potential applications in monitoring timely enzyme activity, complex biological events as well as accurate pharmacological and pharmacokinetic properties. This review provides a systematic summary and insight of the whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains. Some rational design strategies, structure-activity relationships and action mechanisms are discussed. The perspectives of the future development of coumarinbased medicinal chemistry are also presented.read more
Citations
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Journal ArticleDOI
Coumarin-Based Small-Molecule Fluorescent Chemosensors.
Duxia Cao,Zhiqiang Liu,Peter Verwilst,Seyoung Koo,Paramesh Jangjili,Jong Seung Kim,Weiying Lin,Weiying Lin +7 more
TL;DR: This comprehensive and critical review of coumarin-based small-molecule fluorescent chemosensors during the period of 2012-2018 may facilitate the development of more powerful fluorescent chemOSensors for broad and exciting applications in the future.
Journal ArticleDOI
Comprehensive Review in Current Developments of Imidazole‐Based Medicinal Chemistry
TL;DR: This work systematically gives a comprehensive review in current developments of imidazole‐based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti‐inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents, together with their potential applications in diagnostics and pathology.
Journal ArticleDOI
Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
TL;DR: This is the first standalone review that emphasis on the assorted retrosynthetic approaches, important targets for molecularly targeted cancer therapy and structure activity relationship studies that highlight the chemical groups responsible for evoking the anticancer potential of coumarin derivatives reported from 2011 to 2014.
Journal ArticleDOI
Current developments of coumarin-based anti-cancer agents in medicinal chemistry
Saeed Emami,Sakineh Dadashpour +1 more
TL;DR: The current developments of coumarin-based anticancer agents are covered and the structure-activity relationship of the most potent compounds are discussed.
Journal ArticleDOI
Coumarin heterocyclic derivatives: chemical synthesis and biological activity
Fernanda G. Medina,Joaquín G. Marrero,Mariana Macías-Alonso,Magdalena C. Gonzalez,Iván Córdova-Guerrero,Ariana G. Teissier Garcia,Soraya Osegueda-Robles +6 more
TL;DR: This review highlights the broad range of science that has arisen from the synthesis of coumarin-linked and fused heterocycle derivatives and their synthesis and biological activity.
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