Cycloadditions of substituted benzopyran-4-ones to electron-rich dienes: a new route to xanthone derivatives
TL;DR: The benzopyranones 1 and 3 reacted with 2,3-dimethyl-1,3butadiene in the presence of titanium (IV) chloride to give the corresponding (4 + 2) cycloadducts 8 and 11, the former undergoing facile deformylation to give 9 and 10.
About: This article is published in Tetrahedron.The article was published on 1987-01-01. It has received 56 citations till now. The article focuses on the topics: Cycloaddition & Xanthone.
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TL;DR: In this article, the distribution of xanthones is examined in relation to the taxonomic divisions of the Guttiferae, and various pharmacological properties of Xanthones are summarized.
305 citations
TL;DR: Compounds 4b-c/5a-c and 9a demonstrated in vitro antitumor activity against P388 leukemia and Antineoplastic activity of the compounds 4b/5b and9a combined with methotrexate was showed using L1210 murine leukemia.
172 citations
TL;DR: The N-methylanilino group in 2-(Nmethylonilino)-3-formylchromones, obtained in high yield by rearrangement of C(4-oxo-4H[1]-benzopyran-3-yl)-N-phenylnitrones to 2-anilino-3 -formyl-chromones followed by N-methylation, undergoes facile nucleophilic substitution by a variety of nitrogen nucleophiles, thereby paving the way for synthesis of novel 2-substituted
85 citations
TL;DR: It is demonstrated that replacement of the chroman ring of ANS-118, a commercial insecticide, with chromanone moiety could result in new compounds with high potent insecticidal activity.
77 citations
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TL;DR: The authors present an examen approfondi de la synthese, des proprietes et des reactions de l'oxo-4 chromenecarbaldehyde-3 and l'utilisation de ses condensats for the preparation of divers systemes chimiques.
81 citations
69 citations
TL;DR: Chromones activated by carbonyl substituents at C-3 were transformed into the corresponding 2-methyl 4-chromanones by treating with lithium dimethylcuprate as discussed by the authors.
32 citations
32 citations
TL;DR: Improved use of organocopper reagents provides a general route to unsymmetrical 2,2-dialkylchomanones and thiochromanones from chromones andThiochromones via a simple addition - oxidation - addition sequence.
29 citations