Cylindrospermopsin: a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii
01 Sep 1992-Journal of the American Chemical Society (American Chemical Society)-Vol. 114, Iss: 20, pp 7941-7942
About: This article is published in Journal of the American Chemical Society.The article was published on 1992-09-01. It has received 534 citations till now. The article focuses on the topics: Cylindrospermopsis raciborskii & Cylindrospermopsis.
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11 Feb 1999
TL;DR: The state of knowledge regarding the principal considerations in the design of programmes and studies for monitoring water resources and supplies and describes the approaches and procedures used as mentioned in this paper, and the information needed for protecting drinking water sources and recreational water bodies from the health hazards caused by cyanobacteria and their toxins.
Abstract: This book describes the present state of knowledge regarding the impact of cyanobacteria on health through the use of water. It considers aspects of risk management and details the information needed for protecting drinking water sources and recreational water bodies from the health hazards caused by cyanobacteria and their toxins. It also outlines the state of knowledge regarding the principal considerations in the design of programmes and studies for monitoring water resources and supplies and describes the approaches and procedures used.
The development of this publication was guided by the recommendations of several expert meetings concerning drinking water (Geneva, December 1995; Bad Elster, June
1996) and recreational water (Bad Elster, June 1996; St Helier, May 1997). An expert meeting in Bad Elster, April 1997, critically reviewed the literature concerning the toxicity of cyanotoxins and developed the scope and content of this book. A draft manuscript was reviewed at an editorial meeting in November 1997, and a further draft was
reviewed by the working group responsible for updating the Guidelines for Drinkingwater Quality in March 1998.
3,131 citations
Cites background from "Cylindrospermopsin: a potent hepato..."
...The toxicity of pure cylindrospermopsin has recently been studied following the identification of the toxin in 1992 (Ohtani et al., 1992)....
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...LD50 being 200 μg kg bw (Ohtani et al., 1992)....
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TL;DR: A review of the relationship between eutrophication, climate change and cyanobacterial blooms in freshwater, estuarine, and marine ecosystems can be found in this paper.
1,675 citations
TL;DR: The current understanding of CTP's including their risk to human health is reviewed to reflect the changing landscape of harmful algal blooms worldwide.
Abstract: Increasingly, harmful algal blooms (HABs) are being reported worldwide due to several factors, primarily eutrophication, climate change and more scientific monitoring. All but cyanobacteria toxin poisonings (CTPs) are mainly a marine occurrence. CTPs occur in fresh (lakes, ponds, rivers and reservoirs) and brackish (seas, estuaries, and lakes) waters throughout the world. Organisms responsible include an estimated 40 genera but the main ones are Anabaena, Aphanizomenon, Cylindrospermopsis, Lyngbya, Microcystis, Nostoc, and Oscillatoria (Planktothrix). Cyanobacteria toxins (cyanotoxins) include cytotoxins and biotoxins with biotoxins being responsible for acute lethal, acute, chronic and sub-chronic poisonings of wild/domestic animals and humans. The biotoxins include the neurotoxins; ana-toxin-a, anatoxin-a(s) and saxitoxins plus the hepatotoxins; microcystins, nodularins and cylindrospermopsins. Confirmations of human deaths from cyanotoxins are limited to exposure through renal dialysis at a haemodialys...
835 citations
Cites background from "Cylindrospermopsin: a potent hepato..."
...The structure of cylindrospermopsin (CYN) (molecular weight = 416 M+H) was elucidated by Ohtani et al. (1992)....
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TL;DR: In this review, the main focus is the aquatic environment and the effects of these toxins to the organisms living there.
589 citations
535 citations