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Cytocompatibility, osseointegration, and bioactivity of three-dimensional porous and nanostructured network on polyetheretherketone.

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TLDR
The results reveal that the pre-osteoblast functions, bone growth, and apatite formation on the SPEEK surfaces are affected by many factors, including positive effects introduced by the 3D porous structure and SO3H groups as well as negative ones due to the low pH environment.
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This article is published in Biomaterials.The article was published on 2013-12-01. It has received 294 citations till now. The article focuses on the topics: Peek & Surface modification.

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Citations
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Applications of polyetheretherketone (PEEK) in oral implantology and prosthodontics

TL;DR: Considering mechanical and physical properties similar to bone, PEEK can be used in many areas of dentistry and further modifications and improving the material properties may increase its applications in clinical dentistry.
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Additive manufacturing of biomaterials.

TL;DR: Key additive manufacturing methods are first introduced followed by AM of different materials, and finally applications of AM in various treatment options are reviewed.
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Current strategies to improve the bioactivity of PEEK

TL;DR: Modified bioactive PEEK will have a wide range of orthopedic applications, and is believed to have a good integration with adjacent bone tissues upon implantation.
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Extrusion-based additive manufacturing of PEEK for biomedical applications

TL;DR: In this paper, a low-cost 3D printing of polyetheretherketone (PEEK)-based medical devices using filament-based extrusion additive manufacturing (AM) process is reported.
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Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties.

TL;DR: It is demonstrated that the developed PEEK/nano-FHA biocomposite has increased biocompatibility and antibacterial activity in vitro, and promoted osseointegration in vivo, which suggests that it holds potential to be applied as dental implant material in dental tissue engineering applications.
References
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Journal ArticleDOI

Porosity of 3D biomaterial scaffolds and osteogenesis.

TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Surface modification of titanium, titanium alloys, and related materials for biomedical applications

TL;DR: A review of surface modification techniques for titanium and titanium alloys can be found in this article, where the authors have shown that the wear resistance, corrosion resistance, and biological properties can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained.
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Alternative Polymer Systems for Proton Exchange Membranes (PEMs)

TL;DR: Devising systems that can conduct protons with little or no water is perhaps the greatest challenge for new membrane materials, and new membranes that have significantly reduced methanol permeability and water transport (through diffusion and electro-osmotic drag) are required for automotive applications.
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On the mechanisms of biocompatibility.

David F. Williams
- 01 Jul 2008 - 
TL;DR: It is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that the material shall do no harm to those tissues, achieved through chemical and biological inertness.
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In vivo corrosion of four magnesium alloys and the associated bone response.

TL;DR: There is a strong rationale that in this research model, high magnesium ion concentration could lead to bone cell activation, and metallic implants made of magnesium alloys degrade in vivo depending on the composition of the alloying elements.
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