Cytokine profile in Egyptian children and adolescents with COVID-19 pneumonia: A multicenter study.
Hala K Shafiek,Hanan Mohamed Abd El Lateef,Naglaa F Boraey,Mohamed Nashat,Ghada A B Abd-Elrehim,Heba Abouzeid,Sahbaa F. M. Hafez,Hassan Shehata,Ahmed A. Elhewala,Alsayed Abdel-Aziz,Nancy M S Zeidan,Mohammed Soliman,Mohammad M. Sallam,Abdalla M Nawara,Elsayed A. Elgohary,Abd-Allah Badr,Dalia Selim,Suzan A Razek,Batoul M. Abdel Raouf,Hani A Elmikaty,Lamya M Ibrahim,Gehan H. Shahin,Rehab M. Nabil,Mohamed A M Ibrahim,Hanan F Salem,Ahmed A M Moustafa,Naglaa A. Elshehawy,Marwa M. Abdel-Aziz,Heba H Eltrawy,Sherif F Osman,Rania A Fouad,Mona R Afify,Mohamed Y Mohamed,Yousif M Yousif,Aly A Yousef,Mohamed A. Arafa +35 more
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In this article, the authors investigated serum levels of a panel of key cytokines in children and adolescents with COVID-19 pneumonia with a primary focus on "cytokine storm" cytokines such as interleukin (IL)-1β, IL-6 and IP-10.Abstract:
BACKGROUND To date, the cytokine profile in children and adolescent with novel coronavirus disease 2019 (COVID-19) has not been reported. OBJECTIVES We investigated serum levels of a panel of key cytokines in children and adolescent with COVID-19 pneumonia with a primary focus on "cytokine storm" cytokines such as interleukin (IL)-1β, IL-6, IL-17, IL-2, IL-4, IL-10, interferon (IFN-γ), tumor necrosis factor (TNF)-α, and two chemokines interferon-inducible protein-10 (IP-10) and IL-8. We also studied whether these cytokines could be potential markers for illness severity in COVID-19 pneumonia. METHODS Ninety-two symptomatic patients aged less than 18 years with confirmed COVID-19 pneumonia and 100 well-matched healthy controls were included in this multi-center study. For all patients, the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory fluid specimens was detected by real-time reverse-transcriptase polymerase chain reaction. We measured serum concentrations of studied cytokines by using flow cytometry. RESULTS Patients with COVID-19 had significantly higher median IL-1β, IL-6, IL-8, IL-10, IL-17, TNF-α, and IP-10 serum levels than did control children (all p < 0.01). Patients with severe COVID-19 pneumonia had significantly higher median IL-1β, IL-6, and IP-10 serum levels as compared with those with moderate COVID-19 pneumonia; all p < 0.01. ROC analysis revealed that three of the studied markers (IL-6, IL-1β, and IP-10) could predict severe COVID-19 pneumonia cases with the largest AUC for IL-6 of 0.893 (95% confidence interval: 0.84-0.98; p < 0.01). CONCLUSION Our study shows that pediatric patients with COVID-19 pneumonia have markedly elevated serum IL-1β, IL-6, IL-8, IL-10, IL-17, TNF-α, and IP-10 levels at the initial phase of the illness indicating a cytokine storm following SARS-CoV-2 infection. Moreover, serum IL-6, IL-1β, and IP-10 concentrations were independent predictors for severe COVID-19 pneumonia.read more
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Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults
Lise Lund Berven,J. Selvakumar,L. Havdal,Tonje Stiansen-Sonerud,Gunnar Einvik,Truls Michael Leegaard,T. Tjade,Annika E. Michelsen,Tom Eirik Mollnes,Vegard Bruun Wyller +9 more
TL;DR: Among non-hospitalized adolescents and young adults with COVID-19 there was significant alterations of plasma inflammatory markers in the subacute stage of the infection, Still, pulmonary function was normal and clinical symptoms were independent of inflammatory and pulmonary function markers, but positively associated with age and female sex.
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Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19
Nancy M S Zeidan,Hanan Abd El Lateef,Dalia Selim,Suzan A. Razek,Ghada A. B. Abd-Elrehim,Mohamed Nashat,Noha ElGyar,N M Waked,Attia A. Soliman,Ahmed Elhewala,Mohamed M Shehab,Ahmed A. Ibraheem,Hassan Shehata,Y. M. Yousif,Nagwa E. Akeel,Mustafa I.A. Hashem,Amani Ibrahin Ali Ahmed,Ahmed A. Emam,Mohamed Abdelmohsen,Mohamed Ahmed,Ahmed S.M. Saleh,Heba H Eltrawy,Gehan H. Shahin,Rehab M. Nabil,Thoraya A.M. Hosny,Mohamed R. Abdelhamed,Mona Afify,Mohammed Alharbi,M. K. Nagshabandi,Muyassar Tarabulsi,Sherif F Osman,Amal S. M. Abd-Elrazek,Manal M. Rashad,Sonya Ahmed El-Gaaly,Said Abdel Baky Gad,Mohamed Yousuf Khalil Mohamed,Khalil Abdelkhalek,Aly A Yousef +37 more
TL;DR: In this article , the authors investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents, and investigated whether VDR receptor (VDR) FokI polymorphism was a genetic marker for susceptibility.
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Air pollution might affect the clinical course of COVID-19 in pediatric patients
Piotr Rzymski,Barbara Poniedziałek,Joanna Rosińska,Przemysław Ciechanowski,Michał Peregrym,Maria Pokorska-Śpiewak,Ewa Talarek,Izabela Zaleska,Paulina Frańczak-Chmura,Malgorzata Pilarczyk,Magdalena Figlerowicz,Izabela Kucharek,Robert Flisiak +12 more
TL;DR: In this paper , the authors examined the association between the clinical manifestation of COVID-19 in unvaccinated pediatric patients hospitalized in Poland (n = 766) and levels of particulate matter 2.5 (PM2.5) and benzo(a)-pyrene (B(a)P) within a week before hospitalization.
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Different clinical features of children and adults in regional outbreak of Delta COVID-19
TL;DR: In this article , the authors compared clinical features of the Delta variant of coronavirus disease 2019 (COVID-19) in children and adults, and found that the proportion of mild patients in the children group (50%) was higher than that in the adults group (17.9%).
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Is There a Similarity in Serum Cytokine Profile between Patients with Periodontitis or 2019-Novel Coronavirus Infection?—A Scoping Review
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References
More filters
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Maximilian Ackermann,Stijn E. Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W. Li,Vincent W. Li,Steven J. Mentzer,Danny Jonigk +13 more
TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.
Journal ArticleDOI
Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy.
TL;DR: Since then, the number of cases identified in Italy has rapidly increased, mainly in northern Italy, but all regions of the country have reported having patients with COVID-19, and Italy now has the second largest number of CO VID-19 cases and also has a very high case-fatality rate.
Journal ArticleDOI
Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
TL;DR: The current understanding of how a dysregulated immune response may cause lung immunopathology leading to deleterious clinical manifestations after pathogenic hCoV infections is reviewed.