Journal ArticleDOI
Cytokines and chemokines in cerebrospinal fluid and serum of adult patients with acute disseminated encephalomyelitis.
Diego Franciotta,Elisabetta Zardini,Sabrina Ravaglia,Giovanni Piccolo,Laura Andreoni,Roberto Bergamaschi,Alfredo Romani,Eleonora Tavazzi,Paola Naldi,Mauro Ceroni,Enrico Marchioni +10 more
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TLDR
The data suggest that the upregulation of chemokines active on neutrophils and Th2 cells differentiates ADEM from MS inflammation, and that both Th1 and Th1 chemokine might be produced in ADEM.About:
This article is published in Journal of the Neurological Sciences.The article was published on 2006-09-25. It has received 55 citations till now. The article focuses on the topics: CSF pleocytosis & CCL1.read more
Citations
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CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review.
TL;DR: Using PubMed database, 83 studies on CSF cytokines and chemokines are reviewed and the pattern of elevation and possible role of cytokines/chemokines as biomarkers in viral and autoimmune inflammatory neurological disorders of the CNS are described.
Journal ArticleDOI
Acute disseminated encephalomyelitis: an acute hit against the brain
TL;DR: Capitalizing on experience based on a large body of well characterized patient data collected both cross-sectionally and longitudinally, pharmacotherapy has been improved and mortality and comorbidities due to ADEM have been reduced.
Journal ArticleDOI
Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis.
TL;DR: The clinically heterogeneous group of idiopathic inflammatory demyelinating diseases of the central nervous system is characterized by several immunopathological patterns that suggest the involvement of diverse pathogenic effector mechanisms.
Journal ArticleDOI
An emerging role for eotaxins in neurodegenerative disease.
TL;DR: Known functions of eotaxin family members during innate immunity are reviewed, and whether and how these molecules might participate in the progression of neurodegenerative diseases are focused on.
Journal ArticleDOI
Acute disseminated encephalomyelitis (ADEM).
TL;DR: A lot of studies on cytokines and chemokines in blood plasma and CSR from patients with ADEM have enabled investigators to get a better insight into some stages of immunopathological processes, leading to an evolvement of the disease, without a more important impact on the clinical diagnosis.
References
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Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.
Journal ArticleDOI
Lymphocyte traffic control by chemokines.
Bernhard Moser,Pius Loetscher +1 more
TL;DR: Recent developments in this area justify the hypothesis that the distinct migration patterns of lymphocytes throughout their life cycle are finely tuned by changing sets of chemokines that are selective for developmentally regulated chemokine receptors.
Journal ArticleDOI
A role for humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica
C. F. Lucchinetti,Raul N. Mandler,Dorian B. McGavern,Wolfgang Brück,Gerald J. Gleich,Richard M. Ransohoff,Corinna Trebst,Brian G. Weinshenker,Dean M. Wingerchuk,Joseph E. Parisi,Hans Lassmann +10 more
TL;DR: The extent of complement activation, eosinophilic infiltration and vascular fibrosis observed in the Devic NMO cases is more prominent compared with that in prototypic multiple sclerosis, and supports a role for humoral immunity in the pathogenesis of NMO.
Journal ArticleDOI
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
Torben Lykke Sørensen,Marie Tani,Jakob Søndergaard Jensen,Virginia Pierce,Claudia F. Lucchinetti,Virginia A Folcik,Shixin Qin,James B. Rottman,Finn Sellebjerg,Robert M. Strieter,Jette L. Frederiksen,Richard M. Ransohoff +11 more
TL;DR: The results imply pathogenic roles for specific chemokine-chemokine receptor interactions in MS and suggest new molecular targets for therapeutic intervention.
Journal ArticleDOI
Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values.
G. Tibbling,H. Link,S. Öhman +2 more
TL;DR: A proposed graphical presentation of CSF/S albumin and IgG-index may facilitate the interpretation of these parameters in routine clinical work.