Journal ArticleDOI
Daily and hourly temporal association between Δ4-androstenedione - induced preterm myometrial contractions and maternal plasma estradiol and oxytocin concentrations in the 0.8 gestation rhesus monkey☆☆☆★★★
Dino A. Giussani,Susan L. Jenkins,Charles A. Mecenas,James A. Winter,M.Barbera O.M. Honnebier,Wen Wu,Peter W. Nathanielsz +6 more
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TLDR
The temporal relationship between delta4-androstenedione-induced preterm switching of myometrial activity patterns from contractures to contractions and maternal plasma estradiol and oxytocin concentrations in the 0.8 gestation rhesus monkey is investigated.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1996-03-01. It has received 18 citations till now. The article focuses on the topics: Oxytocin Measurement & Androstenedione.read more
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Book ChapterDOI
Brain preparations for maternity--adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview.
TL;DR: The part played by oxytocin neurons and their regulatory mechanisms is reviewed to illustrate how neural systems involved in maternity are prepared in pregnancy via changes in phenotype, synaptic organization and in the relative importance of their different inputs, to function optimally when needed.
Journal ArticleDOI
Neuroendocrine Mechanisms in Pregnancy and Parturition
TL;DR: Evidence for a premature activation of OT secretion as well as increased maternal plasma CRH levels suggests a pathogenic role of these neurohormones, and placental hypersecretion of CRH or Ucn has been proposed as a predictive marker of subsequent preterm delivery.
Journal ArticleDOI
Sex, parturition and motherhood without oxytocin?
John A. Russell,Gareth Leng +1 more
TL;DR: In both types of oxytocin gene disablement, the only evident defect was a complete failure of postpartum homozygotes to transfer milk to the suckling young, which consequently did not survive unless the mothers were treated with exogenous oxytocIn, and these findings are surprising in view of the vast literature on a wide range of species suggesting important roles for oxytoc in regulating gonadal function, in expression of sexual behaviour, in parturition and initiation of maternal behaviour as well as
Journal ArticleDOI
Steroid hormone control of myometrial contractility and parturition.
Sam Mesiano,Toni Welsh +1 more
TL;DR: This review addresses current understanding of how progesterone and estrogens affect the contractility of the pregnancy myometrium and how their actions are coordinated and controlled as part of the parturition cascade.
Journal ArticleDOI
Endocrinology of parturition
TL;DR: In this paper, the authors reviewed the current understanding of the parturition cascade responsible for spontaneous onset of labor at term and discussed preterm labor and post-term pregnancy, and concluded that preterm birth is associated with significant increase in perinatal morbidity and mortality.
References
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Journal ArticleDOI
Effect of corticosteroids for fetal maturation on perinatal outcomes, February 28-March 2, 1994
L. C. Gilstrap,R. Christensen,William H. Clewell,Mary E. D'Alton,E. C. Davidson,M. B. Escobedo,D. K. Gjerdingen,J. Goddard-Finegold,Robert L. Goldenberg,D. A. Grimes,T. N. Hansen,R. E. Kauffman,E. B. Keeler,William Oh,Elizabeth J. Susman,M. G. Vogel +15 more
TL;DR: The consensus panel concluded that antenatal corticosteroid therapy for fetal maturation reduces mortality, respiratory distress syndrome, and intraventricular hemorrhage in preterm infants and will result in a substantial decrease in neonatal morbidity and mortality, as well as substantial savings in health care costs.
Book ChapterDOI
The mechanism of initiation of parturition in the ewe.
TL;DR: In this article, the authors discuss the mechanism of initiation of parturition in the ewe and describe a study that has been carried out on sheep to determine the extent to which the lamb shares in the mechanisms of initiation, to elucidate the means of its participation, and to unravel the intricate endocrine relationship between the conceptus and the mother.
Journal ArticleDOI
Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins
Journal ArticleDOI
Placental steroid hormone biosynthesis in primate pregnancy.
TL;DR: The basic mechanisms underlying regulation of steroidogenesis within the fetoplacental unit during primate pregnancy appear similar, in important ways, to those of widely used laboratory animals, such as the rat and rabbit.
Journal ArticleDOI
Endocrinology of human parturition: a review
Anna-Riitta Fuchs,Fritz Fuchs +1 more
TL;DR: It is proposed that the co‐ordinating of oxytocin receptor formation, PG synthesis and gap junction formation is a key to the initiation and maintenance of human labour.
Related Papers (5)
Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion
Charles A. Mecenas,Dino A. Giussani,Dino A. Giussani,James R. Owiny,James R. Owiny,Susan L. Jenkins,Susan L. Jenkins,Wen X. Wu,Wen X. Wu,Barbera O. Honnebier,Barbera O. Honnebier,Charles J. Lockwood,Charles J. Lockwood,Linda Kong,Linda Kong,Seth Guller,Seth Guller,Peter W. Nathanielsz,Peter W. Nathanielsz +18 more