Decoding a Salmonella Typhi Regulatory Network that Controls Typhoid Toxin Expression within Human Cells
Casey C. Fowler,Jorge E. Galán +1 more
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TLDR
FAST-INSeq, a genome-wide screening approach to identify S. Typhi genes required for typhoid toxin expression within infected cells, finds that Typhi toxin expression is controlled by a silencing and counter-silencing mechanism through the opposing actions of the PhoP/PhoQ two-component regulatory system and the histone-like protein H-NS.About:
This article is published in Cell Host & Microbe.The article was published on 2018-01-10 and is currently open access. It has received 37 citations till now. The article focuses on the topics: Salmonella typhi & Typhoid fever.read more
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Present applications of titanium dioxide for the photocatalytic removal of pollutants from water: A review.
K. P. Gopinath,Nagarajan Vikas Madhav,Abhishek Krishnan,Rajagopal Malolan,Goutham Rangarajan +4 more
TL;DR: This study thoroughly scrutinizes recent applications of titanium dioxide and its modified forms as photocatalytic materials in the removal and control of several classes of water pollutants as reported in literature.
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A decade of advances in transposon-insertion sequencing
TL;DR: The recent applications of TIS to answer overarching biological questions are discussed and emerging and multidisciplinary methods that build on TIS are explored, with an eye towards future applications.
Journal ArticleDOI
The Capsule Regulatory Network of Klebsiella pneumoniae Defined by density-TraDISort.
Matthew J. Dorman,Theresa Feltwell,David Goulding,Julian Parkhill,Francesca L. Short,Francesca L. Short +5 more
TL;DR: It is shown that capsule production in K. pneumoniae is at the center of a complex regulatory network involving multiple global regulators and environmental cues and that the majority of capsule regulatory genes are located in the core genome.
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Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella
Meixin Chen,Hui Sun,Maikel Boot,Lin Shao,Shu-Jung Chang,Weiwei Wang,TuKiet T. Lam,Maria Lara-Tejero,E. Hesper Rego,Jorge E. Galán +9 more
TL;DR: These studies provide a link between a metabolite produced in the mitochondria after stimulation of innate immune receptors and a cell-autonomous defense mechanism that restricts the replication of an intracellular bacterial pathogen.
References
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Book
Experiments in molecular genetics
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Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.
TL;DR: The tight regulation of the PBAD promoter is exploited to study the phenotypes of null mutations of essential genes and the use of pBAD vectors as an expression system is explored.
Journal ArticleDOI
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer
TL;DR: The efficacy of this cDNA cloning strategy was demonstrated by isolating cDNA clones of mRNA from int-2, a mouse gene that expresses four different transcripts at low abundance, the longest of which is approximately 2.9 kilobases.
Journal ArticleDOI
The global burden of typhoid fever.
TL;DR: New data and improved understanding of typhoid fever epidemiology enabled us to refine the global typhoid burden estimate, which remains considerable.
Journal ArticleDOI
Construction of versatile low-copy-number vectors for cloning, sequencing and gene expression in Escherichia coli.
Rongfu Wang,Sidney R. Kushner +1 more
TL;DR: Using the polymerase chain reaction and standard recombinant DNA techniques, a series of new multipurpose low-copy-number plasmids have been constructed, very useful for analyzing genes encoding proteins which are toxic in Escherichia coli in high copy number.
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