Journal ArticleDOI
Deep learning
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TLDR
Deep learning is making major advances in solving problems that have resisted the best attempts of the artificial intelligence community for many years, and will have many more successes in the near future because it requires very little engineering by hand and can easily take advantage of increases in the amount of available computation and data.Abstract:
Deep learning allows computational models that are composed of multiple processing layers to learn representations of data with multiple levels of abstraction. These methods have dramatically improved the state-of-the-art in speech recognition, visual object recognition, object detection and many other domains such as drug discovery and genomics. Deep learning discovers intricate structure in large data sets by using the backpropagation algorithm to indicate how a machine should change its internal parameters that are used to compute the representation in each layer from the representation in the previous layer. Deep convolutional nets have brought about breakthroughs in processing images, video, speech and audio, whereas recurrent nets have shone light on sequential data such as text and speech.read more
Citations
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Journal ArticleDOI
The frontier of simulation-based inference
TL;DR: The rapidly developing field of simulation-based inference is reviewed and the forces giving additional momentum to the field are identified to describe how the frontier is expanding.
Journal ArticleDOI
Automatic segmentation of nine retinal layer boundaries in OCT images of non-exudative AMD patients using deep learning and graph search.
TL;DR: A novel framework combining convolutional neural networks (CNN) and graph search methods (termed as CNN-GS) for the automatic segmentation of nine layer boundaries on retinal optical coherence tomography (OCT) images is presented.
Journal ArticleDOI
Conscious Processing and the Global Neuronal Workspace Hypothesis.
George A. Mashour,Pieter R. Roelfsema,Pieter R. Roelfsema,Jean-Pierre Changeux,Jean-Pierre Changeux,Jean-Pierre Changeux,Stanislas Dehaene,Stanislas Dehaene +7 more
TL;DR: The GNW hypothesis proposes that, in the conscious state, a non-linear network ignition associated with recurrent processing amplifies and sustains a neural representation, allowing the corresponding information to be globally accessed by local processors.
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From machine learning to deep learning: progress in machine intelligence for rational drug discovery.
TL;DR: The history of machine learning is summarized and insight into recently developed deep learning approaches and their applications in rational drug discovery are provided to help guide early-stage drug design and discovery in the current big data era.
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Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery
TL;DR: The current state-of-the art of AI-assisted pharmaceutical discovery is discussed, including applications in structure- and ligand-based virtual screening, de novo drug design, physicochemical and pharmacokinetic property prediction, drug repurposing, and related aspects.
References
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Journal ArticleDOI
Long short-term memory
TL;DR: A novel, efficient, gradient based method called long short-term memory (LSTM) is introduced, which can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units.
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Gradient-based learning applied to document recognition
Yann LeCun,Léon Bottou,Léon Bottou,Yoshua Bengio,Yoshua Bengio,Yoshua Bengio,Patrick Haffner +6 more
TL;DR: In this article, a graph transformer network (GTN) is proposed for handwritten character recognition, which can be used to synthesize a complex decision surface that can classify high-dimensional patterns, such as handwritten characters.
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Learning representations by back-propagating errors
TL;DR: Back-propagation repeatedly adjusts the weights of the connections in the network so as to minimize a measure of the difference between the actual output vector of the net and the desired output vector, which helps to represent important features of the task domain.
Journal ArticleDOI
Human-level control through deep reinforcement learning
Volodymyr Mnih,Koray Kavukcuoglu,David Silver,Andrei Rusu,Joel Veness,Marc G. Bellemare,Alex Graves,Martin Riedmiller,Andreas K. Fidjeland,Georg Ostrovski,Stig Petersen,Charles Beattie,Amir Sadik,Ioannis Antonoglou,Helen King,Dharshan Kumaran,Daan Wierstra,Shane Legg,Demis Hassabis +18 more
TL;DR: This work bridges the divide between high-dimensional sensory inputs and actions, resulting in the first artificial agent that is capable of learning to excel at a diverse array of challenging tasks.
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Reducing the Dimensionality of Data with Neural Networks
TL;DR: In this article, an effective way of initializing the weights that allows deep autoencoder networks to learn low-dimensional codes that work much better than principal components analysis as a tool to reduce the dimensionality of data is described.