Journal ArticleDOI
Defective cardiac parasympathetic control in patients with heart disease.
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TLDR
Baroreceptor-induced slowing of heart rate in normal subjects was shown to be mediated by the parasympathetic nervous system since it could be abolished with atropine.Abstract:
To define the state of the parasympathetic nervous system in heart failure, parasympathetic blockade with atropine was induced after adrenergic blockade with propranolol in 12 normal subjects and in nine patients with heart disease. Atropine elevated heart rate by 55 ± 9 per cent in normal subjects, but by only 23 ± 8 per cent in patients with heart disease (p less than 0.05). In 23 control subjects and 22 patients, transient elevations in arterial pressure were produced by intravenous injections of phenylephrine, and successive R-R intervals were plotted as a function of systolic pressure. The slowing of heart rate per unit rise in systolic arterial pressure averaged 16.0 ±1.8 msec per millimeter of mercury in normal subjects but only 3.70 ± 0.8 msec per millimeter of mercury in the patients (p less than 0.001). Baroreceptor-induced slowing of heart rate in normal subjects was shown to be mediated by the parasympathetic nervous system since it could be abolished with atropine. These findings poi...read more
Citations
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Journal ArticleDOI
Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction
TL;DR: The ATRAMI study as discussed by the authors provides clinical evidence that after myocardial infarction the analysis of vagal reflexes has significant prognostic value independently of LVEF and ventricular arrhythmias and that it significantly adds to the prognosis value of heartrate variability.
Journal ArticleDOI
Controlled trial of physical training in chronic heart failure: Exercise performance, hemodynamics, ventilation, and autonomic function
Andrew J.S. Coats,S. Adamopoulos,A Radaelli,A McCance,T E Meyer,Luciano Bernardi,P L Solda,P Davey,O Ormerod,C Forfar +9 more
TL;DR: Carefully selected patients with moderate to severe CHF can achieve significant, worthwhile improvements with exercise training, and autonomic balance was altered by physical training when assessed by three methods.
Journal ArticleDOI
Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure
Katsuji Imai,Hideyuki Sato,Masatsugu Hori,Hideo Kusuoka,Hitoshi Ozaki,Hiroshi Yokoyama,Hiroshi Takeda,Michitoshi Inoue,Takenobu Kamada +8 more
TL;DR: The results indicate that T30 is mediated primarily by vagal reactivation, independent of sympathetic withdrawal, and is significantly smaller in athletes and significantly larger in patients with chronic heart failure than that in respective age-matched normal control subjects.
Journal ArticleDOI
Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis.
J. Philip Saul,J. Philip Saul,J. Philip Saul,Yutaka Arai,Yutaka Arai,Yutaka Arai,Ronald D. Berger,Ronald D. Berger,Ronald D. Berger,Leonard S. Lilly,Leonard S. Lilly,Leonard S. Lilly,Wilson S. Colucci,Wilson S. Colucci,Wilson S. Colucci,Richard J. Cohen,Richard J. Cohen,Richard J. Cohen +17 more
TL;DR: The frequency characteristics of HR fluctuations in patients with severe CHF are consistent with abnormal baroreflex responsiveness to physiologic stimuli, and suggest that there is diminished vagal, but relatively preserved sympathetic, modulation of HR.
Journal ArticleDOI
Prognostic Value of Nocturnal Cheyne-Stokes Respiration in Chronic Heart Failure
Paola Lanfranchi,Alberto Braghiroli,Enzo Bosimini,Giorgio Mazzuero,Roberto Colombo,Claudio F. Donner,Pantaleo Giannuzzi +6 more
TL;DR: The AHI is a powerful independent predictor of poor prognosis in clinically stable patients with CHF and patients at very high risk for subsequent cardiac death could be identified by an AHI >/=30/h and left atria
References
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Journal ArticleDOI
Reflex Regulation of Arterial Pressure during Sleep in Man: A Quantitative Method of Assessing Baroreflex Sensitivity
TL;DR: It is concluded that the baroreceptor reflex are can be rapidly reset, particularly during sleep, and the lower arterial pressures during sleep may be actively maintained in some subjects by increased baroreflex sensitivity.
Journal ArticleDOI
Diminished Baroreflex Sensitivity in High Blood Pressure
TL;DR: Reduced sensitivity of the baroreflexes in hypertension, with respect to control of heart rate is demonstrated, and a distinction is made between this change in sensitivity and simple resetting of the reflex.
Journal ArticleDOI
Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failure.
TL;DR: It is concluded that heart failure is associated with augmented activity of the sympathetic nervous system, reflected in increased norepinephrine excretion and often associated with a deficit of cardiac norpinephrine.
Journal ArticleDOI
The normal range and determinants of the intrinsic heart rate in man.
Anthony D. Jose,D. Collison +1 more
TL;DR: Normal standards for the intrinsic heart rate (IHR) were measured in 432 healthy adult subjects aged 16 to 70 years and in different subjects, age was the only important determinant.
Journal ArticleDOI
Augmentation of the plasma nor-epinephrine response to exercise in patients with congestive heart failure.
TL;DR: In patients in whom the cardiac reserve is diminished, the normal increase of cardiac output during exercise is attenuated, or even abolished, and Diminished activity of this important reserve mechanism could be a factor in the abnormal cardiac activity.