Journal ArticleDOI
Degeneration and regeneration of the nervous system
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This article is published in Electroencephalography and Clinical Neurophysiology.The article was published on 1960-05-01. It has received 1975 citations till now. The article focuses on the topics: Degeneration (medical) & Regeneration (biology).read more
Citations
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Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
Journal ArticleDOI
Regeneration beyond the glial scar
Jerry Silver,Jared H. Miller +1 more
TL;DR: Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.
Journal ArticleDOI
Adult neurogenesis in the mammalian central nervous system
Guo Li Ming,Hongjun Song +1 more
TL;DR: Advances in the understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.
Journal ArticleDOI
Reactive astrocytes protect tissue and preserve function after spinal cord injury.
Jill R. Faulkner,Julia E. Herrmann,Michael J. Woo,Keith E. Tansey,Ngan B. Doan,Michael V. Sofroniew +5 more
TL;DR: The findings show that reactive astrocytes provide essential activities that protect tissue and preserve function after mild or moderate SCI, and suggest that identifying ways to preserve reactive astracytes, to augment their protective functions, or both, may lead to novel approaches to reducing secondary tissue degeneration and improving functional outcome after SCI.
Journal ArticleDOI
Glial inhibition of CNS axon regeneration
Glenn Yiu,Zhigang He +1 more
TL;DR: The molecular basis of inhibitory molecules in CNS myelin as well as proteoglycans associated with astroglial scarring are evaluated and their contributions to the limitation of long-distance axon repair and other types of structural plasticity are evaluated.
References
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Journal ArticleDOI
Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
Journal ArticleDOI
Regeneration beyond the glial scar
Jerry Silver,Jared H. Miller +1 more
TL;DR: Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.
Journal ArticleDOI
Adult neurogenesis in the mammalian central nervous system
Guo Li Ming,Hongjun Song +1 more
TL;DR: Advances in the understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.
Journal ArticleDOI
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
TL;DR: This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases.
Journal ArticleDOI
Reactive astrocytes protect tissue and preserve function after spinal cord injury.
Jill R. Faulkner,Julia E. Herrmann,Michael J. Woo,Keith E. Tansey,Ngan B. Doan,Michael V. Sofroniew +5 more
TL;DR: The findings show that reactive astrocytes provide essential activities that protect tissue and preserve function after mild or moderate SCI, and suggest that identifying ways to preserve reactive astracytes, to augment their protective functions, or both, may lead to novel approaches to reducing secondary tissue degeneration and improving functional outcome after SCI.