Dehydropipernonaline, an Amide Possessing Coronary Vasodilating Activity, Isolated from Piper Iongum L
TL;DR: An amide (dehydropipernonaline) that has coronary vasorelaxant activity was isolated from the fruit of Piper longum L and characterized on the basis of spectroscopic data.
About: This article is published in Journal of Pharmaceutical Sciences.The article was published on 1986-12-01. It has received 46 citations till now.
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TL;DR: This study provides detailed information about the P. longum fruit, including phytochemistry, pharmacological profile and safety profile, and in view of the commercial, economic, and medicinal importance of the plant, it is useful for researchers to study the plant in detail.
135 citations
01 Jan 2004
131 citations
TL;DR: Despite traditional claims, insufficient scientific validation for the treatment of insomnia, dementia, epilepsy, rheumatoid arthritis, asthma, spleen disorder, puerperal fever and leprosy, necessitate future investigations in this direction.
80 citations
TL;DR: The 80% aqueous acetone extract from the fruit of Piper chaba (Piperaceae) was found to have hepatoprotective effects on D-galactosamine (D-GalN)/lipopolysaccharide-induced liver injury in mice, and the following structural requirements were suggested.
79 citations
TL;DR: Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF, except for that induced by thrombin.
77 citations
Cites background from "Dehydropipernonaline, an Amide Poss..."
...Piper species are distributed widely in the tropical and subtropical regions of the world, have multiple applications in different folk medicines, including the Indian Ayurvedic system, and have been reported to possess numerous biological activities (Stöhr et al., 2001; Shoji et al., 1986; Lee, 2000; Rege et al., 1999; Tripathi et al., 1999)....
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59 citations
TL;DR: Aus Piper nigrum werden drei neue Nebenalkaloide isoliert as mentioned in this paper, i.e., chavicin is not a cis.cis-Piperin, sondern ein Gemisch aus Piperin and verschiedenen NebenALKaloiden.
Abstract: Aus Piper nigrum werden drei neue Nebenalkaloide isoliert. Das „Chavicin”, das bisher als Geschmackstrager des Pfeffers angegeben wurde, ist kein cis.cis-Piperin, sondern ein Gemisch aus Piperin und verschiedenen Nebenalkaloiden; cis.cis-Piperin kann im Pfeffer nicht nachgewiesen werden. Samtliche cis-trans-isomeren Piperinsauren und ihre Piperidide werden synthetisiert. Ihre Eigenschaften beweisen ebenfalls, das das „Chavicin” der alteren Literatur kein Isomeres des Piperins gewesen sein kann. Der scharfe Geschmack des Pfeffers wird durch Piperin verursacht.
50 citations