Open AccessJournal Article
Delirium: acute confusional state
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It is found that patients who had had delirium had higher two-year mortality rates and greater loss of independence than control patients and that poor outcomes might be avoided, in part, with early diagnosis and appropriate management ofDelirium.Abstract:
Many clinicians do not realize the costs associated with delirium. Francis and Kapoor found that patients who had had delirium had higher two-year mortality rates and greater loss of independence than control patients. The investigators also reported a trend toward decline in cognitive performance among patients who had had delirium. Levkoff and coworkers found that delirium was associated with no change in mortality, but that it was associated with prolonged hospital stays and an increased risk of institutional placement among community dwelling elderly. Poor outcomes might be avoided, in part, with early diagnosis and appropriate management of delirium.read more
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Journal ArticleDOI
The prognostic significance of delirium in older hospital patients.
Shaun T. O'Keeffe,J. N. Lavan +1 more
TL;DR: To determine whether delirium is an independent predictor of adverse outcomes of hospitalization in older patients, a large number of patients with dementia and a history of psychosis are studied.
Journal ArticleDOI
Drug-Induced Cognitive Impairment in the Elderly
Alan R. Moore,Shaun T. O'Keeffe +1 more
TL;DR: Delirium was a major complication of treatment with tricyclic antidepressants but seems less common with newer agents, and the total burden of anticholinergic drugs may determine development of delirium rather than any single agent.
Journal ArticleDOI
Clinical significance of delirium subtypes in older people.
Shaun T. O'Keeffe,J. N. Lavan +1 more
TL;DR: Patients with hypoactive delirium were sicker on admission, had the longest hospital stay and were most likely to develop pressure sores and fall in hospital, while patients with hyperactive delIRium were mostlikely toFall in hospital.
Journal ArticleDOI
Pediatric delirium in critical illness: phenomenology, clinical correlates and treatment response in 40 cases in the pediatric intensive care unit.
Jan N. M. Schieveld,Piet L. J. M. Leroy,Jim van Os,Joost Nicolai,Gijs D. Vos,Albert F.G. Leentjens +5 more
TL;DR: The rate of delirium in critically ill children on a PICU is not negligible, yet prospective studies of the phenomenology, risk factors and treatment of childhood deliria are very rare.
Journal ArticleDOI
Inflammation and Alzheimer's Disease: Relationships between Pathogenic Mechanisms and Clinical Expression
TL;DR: The present data indicate that inflammatory processes in the brain contribute to the etiology, the pathogenesis, and the clinical expression of AD.