Book ChapterDOI
Dendrimer-based nanoformulations as drug carriers for cancer treatment
Narsireddy Amreddy,Mahendran Chinnappan,Anupama Munshi,Rajagopal Ramesh +3 more
- pp 137-159
Reads0
Chats0
TLDR
This chapter discusses the different methods for the synthesis of dendrimers, and highlights designing d endrimers with biocompatible properties for cancer therapy.Abstract:
Nanomedicine has received significant attention as drug delivery systems for cancer therapy. Nanoparticle drug delivery systems are widely studied for different formulations in anticancer drug and gene delivery. Dendrimers are polymer-based nanoparticles that are used for improving therapeutic efficiency where conventional chemotherapy has disadvantages. This chapter discusses the different methods for the synthesis of dendrimers. The chemistry and structure properties of dendrimers are provided. We highlight designing dendrimers with biocompatible properties for cancer therapy. This chapter also gives an overview of dendrimers used in cancer therapy, provides an outline of different cancer types, and offers examples of dendrimers used in anticancer agent complexes.read more
Citations
More filters
Journal ArticleDOI
Safety Challenges and Application Strategies for the Use of Dendrimers in Medicine
TL;DR: How technology can be used to reduce dendrimer toxicity, by changing their size and surface functionalization, how d endrimers can be combined with other materials to generate a composite formulation, and how dendedrimersCan be used for the diagnosis of disease are described.
Journal Article
[Preoperative chemotherapy in non-small cell lung cancer: advantages, disadvantages, level of evidence].
A. Depierre,Westeel +1 more
TL;DR: The combination of chemotherapy and surgery is a standard of care for non-small cell lung cancer, as shown by the recently published "Standards, Options and Recommandations" (SOR) by the Fédération des Centres de Lutte contre le Cancer.
References
More filters
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Gene therapy -- promises, problems and prospects
Inder M. Verma,Nikunj V. Somia +1 more
TL;DR: The prospects are good — by the year 2010, gene therapy may be as routine a practice as heart transplants are today.
Journal ArticleDOI
Therapeutic Nanoparticles for Drug Delivery in Cancer
TL;DR: In this paper, the authors proposed a passive targeting mechanism, active targeting strategies using ligands or antibodies directed against selected tumor targets amplify the specificity of these therapeutic nanoparticles, enabling them to carry their loaded active drugs to cancer cells by selectively using the unique pathophysiology of tumors.
Journal Article
Therapeutic Nanoparticles for Drug Delivery in Cancer
TL;DR: Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment.