Dendritic cell control of tolerogenic responses.
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Cites background from "Dendritic cell control of tolerogen..."
...Signals from the intestinal tissue microenvironment, including epithelial cell-derived thymic stromal lyphopoietin (TSLP) and bile acid retinoids, condition CD103CD11b LPDCs to preferentially generate T regulatory cells once these DCs have trafficked to the mesenteric lymph nodes (Manicassamy and Pulendran, 2011)....
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...…tissue microenvironment, including epithelial cell-derived thymic stromal lyphopoietin (TSLP) and bile acid retinoids, condition CD103+CD11b+ LPDCs to preferentially generate T regulatory cells once these DCs have trafficked to the mesenteric lymph nodes (Manicassamy and Pulendran, 2011)....
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342 citations
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Cites background from "Dendritic cell control of tolerogen..."
...However, even in multiple environmental milieus, the various DC subsets often share the ability to stimulate T cell proliferation or induce their unresponsiveness (3-5)....
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...Immature DCs express low levels of MHC and co-stimulatory molecules and unable to efficiently activate T cells, although their endocytic potential is high (3-5)....
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...It was shown that cDC, including tissue-resident DCs, migratory DCs and inflammatory DCs might exhibit immunosuppressive properties under certain circumstances or in immature stage (3-5)....
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References
7,494 citations
"Dendritic cell control of tolerogen..." refers background in this paper
...In general, TLR-9-activation of DCs promotes Th1 responses (113)....
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6,987 citations
"Dendritic cell control of tolerogen..." refers background in this paper
...The innate immune system relies on a diverse array of receptors that can sense components of pathogens (92, 93)....
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6,308 citations
"Dendritic cell control of tolerogen..." refers background in this paper
...Furthermore, anti-inflammatory cytokines such IL-10 produced by DCs play a critical role in establishing chronic infection (274)....
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5,811 citations
"Dendritic cell control of tolerogen..." refers background in this paper
...These cells may augment the immunosuppressive effects of tolerogenic DCs (203)....
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5,042 citations