Dendritic cells and the control of immunity
Citations
10,451 citations
8,041 citations
Cites background from "Dendritic cells and the control of ..."
...Upon encountering a pathogen, they undergo a developmental program called dendritic cell maturation, which includes induction of costimulatory activity, antigen processing, increased MHC molecule expression, and migration to the lymph node, where they can prime na ̈ ıve antigen-specific T cells (4)....
[...]
...Dendritic cells are pivotally positioned at the interface of innate and adaptive immunity (4)....
[...]
...It does so through the expression of costimulatory molecules, such as CD80 and CD86, on the surface of specialized antigen-presenting cells, the most important of which are the dendritic cells that guard against infection in virtually all tissues (1, 3, 4)....
[...]
6,758 citations
[...]
5,915 citations
5,537 citations
Additional excerpts
...BIOGEN 34 38 5 Originally published as Nature 401 , 708 – 712 ; 1999 Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cell...
[...]
References
5,381 citations
3,852 citations
2,674 citations
2,437 citations
2,306 citations