Journal ArticleDOI
Dendritic cells, T cells and lymphatics: dialogues in migration and beyond
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TLDR
In conclusion, these novel results provide important insights on intimate connections between LECs and leukocytes that contribute to the understanding of immune responses.About:
This article is published in Current Opinion in Immunology.The article was published on 2018-08-01. It has received 28 citations till now. The article focuses on the topics: Lymphatic system & T cell.read more
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Journal ArticleDOI
Fates of CD8+ T cells in Tumor Microenvironment.
TL;DR: A thorough understanding of factors contributing to the fates of CD8+ T cells will allow researchers to develop new strategies and improve on already existing strategies to facilitate CD8- T cell mediated anti-tumor function, impede T cell dysfunction and modulate the TME into a less immunosuppressive TME.
Journal ArticleDOI
Lymphatic Migration of Immune Cells
TL;DR: The significance and mechanisms of lymphatic migration of innate and adaptive immune cells in homeostasis, inflammation and cancer are discussed.
Journal ArticleDOI
Leucocyte Trafficking via the Lymphatic Vasculature- Mechanisms and Consequences
TL;DR: The emerging importance of the leucocyte glycocalyx and its novel interactions with the endothelial receptor LYVE-1, the intricacies of endothelial chemokine secretion and sequestration that direct leucocytes trafficking and the significance of the process for normal immune function and pathology are highlighted.
Journal ArticleDOI
ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions.
Ann Helen Willrodt,Ann-Charlott Salabarria,Philipp Schineis,Desislava Ignatova,Morgan Campbell Hunter,Martina Vranova,Alexandra Michaela Golding-Ochsenbein,Elena C. Sigmund,Annatina Romagna,Verena Strassberger,Marina Fabbi,Silvano Ferrini,Claus Cursiefen,Dario Neri,Emmanuella Guenova,Felix Bock,Cornelia Halin +16 more
TL;DR: This study identified and characterized a monoclonal antibody with high affinity and specificity for murine ALCAM and found that it reduced in vitro T cell activation induced by antigen-presenting dendritic cells (DCs) as well as (trans)migration of murine DCs across lymphatic endothelial monolayers.
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CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo .
Swantje I. Hammerschmidt,Kathrin Werth,Michael Rothe,Melanie Galla,Marc Permanyer,Gwendolyn E. Patzer,Anja Bubke,David N. Frenk,Anton Selich,Lucas Lange,Axel Schambach,Berislav Bošnjak,Reinhold Förster +12 more
TL;DR: This study combines unlimited proliferative capacity of conditionally Hoxb8-immortalized hematopoietic progenitor cells with CRISPR/Cas9 technology to create a powerful experimental system to investigate DC migration and function and provides a platform for the immunoengineering of DCs that can be exploited to further dissect DC dynamics in vivo.
References
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Journal ArticleDOI
Tissue-Resident Memory T Cells
Jason M. Schenkel,David Masopust +1 more
TL;DR: This review will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population.
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Dendritic cell migration in health and disease
TL;DR: This Review focuses on new insights concerning the role of migratory DCs in the pathogenesis of diseases of the skin, intestine, lung, and brain, as well as in autoimmunity and atherosclerosis.
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Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics.
TL;DR: This study establishes a molecular basis for T cell exit from peripheral tissues by demonstrating that the chemokine receptor CCR7 is a critical signal that determines T cellexit from peripheral tissue.
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Different patterns of peripheral migration by memory CD4 + and CD8 + T cells
Thomas Gebhardt,Paul G. Whitney,Ali Zaid,Laura K. Mackay,Andrew G. Brooks,William R. Heath,Francis R. Carbone,Scott N. Mueller +7 more
TL;DR: Overall, these results identify a complexity in memory T-cell migration, illuminating previously unappreciated differences between the CD4+ and CD8+ subsets.
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Interstitial dendritic cell guidance by haptotactic chemokine gradients.
Michele Weber,Robert Hauschild,Jan Schwarz,Christine Moussion,Ingrid de Vries,Daniel F. Legler,Sanjiv A. Luther,Tobias Bollenbach,Michael Sixt +8 more
TL;DR: These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.