Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.
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Cites background from "Dendritic cells use macropinocytosi..."
...Whereas the MMR is prominent on human monocyte–derived DCs in culture (105), this receptor has yet to be detected on DCs in the T cell areas of lymphoid organs in either mice (106) or humans (107)....
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2,935 citations
References
5,381 citations
"Dendritic cells use macropinocytosi..." refers background or methods in this paper
...The method for the in vitro culture of human DCs has been described (9)....
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...Strikingly, stimulation with TNF-ot results in an inhibition of the capacity to present a soluble antigen and, at the same time, an increase in T cell stimulatory capacity (9)....
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...The upregulation of CD44V expression (9) and possibly downregulation of E-cadherin (40) may change their migratory properties....
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...We have recently described an in vitro culture system using GM-CSF and IL-4 that permits DCs to be maintained in a state where they are competent for antigen capture and processing (9)....
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4,872 citations
"Dendritic cells use macropinocytosi..." refers background in this paper
...Dendritric cells (DCs) 1 play a critical role in antigen presentation in vivo since they are the specialized APCs that prime virgin T cells (6)....
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...A breakthrough in understanding the function of DCs has been the identification of two stages of maturation (6)....
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...This property is rapidly lost when DCs, after in vivo antigenic challenge, move to the T celldependent areas of secondary lymphoid organs (6)....
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4,825 citations
"Dendritic cells use macropinocytosi..." refers background in this paper
...It is tempting to speculate that the capacity of DCs to respond with these changes to inflammatory cytokines or exogenous bacterial products might have developed to favor the earliest possible recognition of invading pathogens, since presentation of antigens from dangerous pathogens will be favored compared to presentation of nondangerous self antigens (41, 42)....
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1,332 citations
"Dendritic cells use macropinocytosi..." refers background in this paper
...It is tempting to speculate that the capacity of DCs to respond with these changes to inflammatory cytokines or exogenous bacterial products might have developed to favor the earliest possible recognition of invading pathogens, since presentation of antigens from dangerous pathogens will be favored compared to presentation of nondangerous self antigens (41, 42)....
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1,327 citations