Dengue in the Americas: challenges for prevention and control

doi:10.1590/S0102-311X2009001300003

Home
/
Papers
/
Dengue in the Americas: challenges for prevention and control

Journal Article•DOI•

Dengue in the Americas: challenges for prevention and control

Héctor Gómez-Dantés, Janine Ramsey Willoquet

01 Jan 2009-Cadernos De Saude Publica (Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz)-Vol. 25

TL;DR: The challenges for prevention and control in the Americas are discussed, with solutions only targeting the vector reduce the impact of interventions and there is no sustainable control.

read less

Abstract: Dengue is the most important vector-borne disease in the Americas and threatens the lifes of millions of people in developing countries. Imprecise morbidity and mortality statistics underestimate the magnitude of dengue as a regional health problem. As a result, it is considered a low priority by the health sector with no timely steps for effective control. Dengue is perceived as a problem of "others" (individually, collectively and institutionally), therefore responsibility for its control is passed on to others (neighbors, the community, municipality, health institutions, or other governmental agencies). With no precise risk indicators available there is little opportunity for timely diagnoses, treatment, health interventions or vector control (poor surveillance). Solutions only targeting the vector reduce the impact of interventions and there is no sustainable control. Without political commitment there are insufficient resources to face the problem. This paper discusses the challenges for prevention and control in the Americas.

...read moreread less

Content maybe subject to copyright Report

Citations

PDF

Open Access

More filters

Journal Article•DOI•

Biological Control of Mosquito Vectors: Past, Present, and Future

[...]

Giovanni Benelli¹, Claire L. Jeffries², Thomas Walker²•Institutions (2)

University of Pisa¹, University of London²

03 Oct 2016-Insects

TL;DR: This review outlines non-insecticide based strategies that have been implemented or are currently being tested, and highlights the use of mosquito behavioural knowledge that can be exploited for control strategies.

...read moreread less

Abstract: Mosquitoes represent the major arthropod vectors of human disease worldwide transmitting malaria, lymphatic ﬁlariasis, and arboviruses such as dengue virus and Zika virus. Unfortunately, no treatment (in the form of vaccines or drugs) is available for most of these diseases andvectorcontrolisstillthemainformofprevention. Thelimitationsoftraditionalinsecticide-based strategies, particularly the development of insecticide resistance, have resulted in signiﬁcant efforts to develop alternative eco-friendly methods. Biocontrol strategies aim to be sustainable and target a range of different mosquito species to reduce the current reliance on insecticide-based mosquito control. In thisreview, weoutline non-insecticide basedstrategiesthat havebeenimplemented orare currently being tested. We also highlight the use of mosquito behavioural knowledge that can be exploited for control strategies.

...read moreread less

267 citations

Journal Article•DOI•

Using web search query data to monitor dengue epidemics: a new model for neglected tropical disease surveillance.

[...]

Emily H. Chan¹, Emily H. Chan², Vikram Sahai³, Corrie Conrad³, John S. Brownstein¹, John S. Brownstein⁴, John S. Brownstein² - Show less +3 more•Institutions (4)

Massachusetts Institute of Technology¹, Boston Children's Hospital², Google³, Harvard University⁴

31 May 2011-PLOS Neglected Tropical Diseases

TL;DR: Web search query data were found to be capable of tracking dengue activity in Bolivia, Brazil, India, Indonesia and Singapore, and represent valuable complement to assist with traditional d Dengue surveillance.

...read moreread less

Abstract: Background A variety of obstacles including bureaucracy and lack of resources have interfered with timely detection and reporting of dengue cases in many endemic countries. Surveillance efforts have turned to modern data sources, such as Internet search queries, which have been shown to be effective for monitoring influenza-like illnesses. However, few have evaluated the utility of web search query data for other diseases, especially those of high morbidity and mortality or where a vaccine may not exist. In this study, we aimed to assess whether web search queries are a viable data source for the early detection and monitoring of dengue epidemics. Methodology/Principal Findings Bolivia, Brazil, India, Indonesia and Singapore were chosen for analysis based on available data and adequate search volume. For each country, a univariate linear model was then built by fitting a time series of the fraction of Google search query volume for specific dengue-related queries from that country against a time series of official dengue case counts for a time-frame within 2003–2010. The specific combination of queries used was chosen to maximize model fit. Spurious spikes in the data were also removed prior to model fitting. The final models, fit using a training subset of the data, were cross-validated against both the overall dataset and a holdout subset of the data. All models were found to fit the data quite well, with validation correlations ranging from 0.82 to 0.99. Conclusions/Significance Web search query data were found to be capable of tracking dengue activity in Bolivia, Brazil, India, Indonesia and Singapore. Whereas traditional dengue data from official sources are often not available until after some substantial delay, web search query data are available in near real-time. These data represent valuable complement to assist with traditional dengue surveillance.

...read moreread less

257 citations

Cites background from "Dengue in the Americas: challenges ..."

...Therefore, the need to take steps to improve dengue surveillance has been well acknowledged [1,4,16], but cost and feasibility remain major obstacles....
[...]
...standings about or unfamiliarity with case definitions, complicated reporting procedures, a tendency to report only the most severe cases, lack of reporting from the private health sector [4,16] and the reality that a proportion of the ill do not seek clinical care whether because they self-treat at home [18] or because their infection is asymptomatic or subclinical [21]....
[...]

Journal Article•DOI•

Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife, Brazil.

[...]

Cynthia Braga¹, Carlos Feitosa Luna¹, Celina Maria Turchi Martelli², Wayner Vieira de Souza¹, Marli Tenório Cordeiro¹, Neal Alexander³, Maria de Fátima Pessoa Militão de Albuquerque¹, Maria de Fátima Pessoa Militão de Albuquerque⁴, José Constantino Silveira Júnior¹, Ernesto T. A. Marques¹, Ernesto T. A. Marques⁵ - Show less +7 more•Institutions (5)

Oswaldo Cruz Foundation¹, Universidade Federal de Goiás², University of London³, Federal University of Pernambuco⁴, Johns Hopkins University⁵

01 Mar 2010-Acta Tropica

TL;DR: Intensive vector control, surveillance and community education should be considered in deprived urban areas where a high proportion of children are infected by an early age and investigation of dengue transmission in small areas is important to formulate control strategies.

...read moreread less

177 citations

Cites result from "Dengue in the Americas: challenges ..."

...The inverse association between dengue infection and wealth is in agreement with previous studies and reinforces the role of socio-economic factors in dengue transmission (Gomez-Dantes and Willoquet, 2009; Teixeira et al., 2002; Reiter et al., 2003)....
[...]

Journal Article•DOI•

Recent rapid rise of a permethrin knock down resistance allele in Aedes aegypti in México.

[...]

Gustavo Ponce García¹, Adriana E. Flores¹, Ildefonso Fernández-Salas¹, Karla Saavedra-Rodriguez², Guadalupe Reyes-Solis², Saul Lozano-Fuentes², J Guillermo Bond, Mauricio Casas-Martínez, Janine M. Ramsey, Julian E. Garcia-Rejon³, Marco Dominguez-Galera, Hilary Ranson⁴, Janet Hemingway⁴, Lars Eisen², William C. Black² - Show less +11 more•Institutions (4)

Universidad Autónoma de Nuevo León¹, Colorado State University², Universidad Autónoma de Yucatán³, Liverpool School of Tropical Medicine⁴

13 Oct 2009-PLOS Neglected Tropical Diseases

TL;DR: A dramatic increase in the frequency of the Ile1,016 mutation in the voltage-gated sodium channel gene of Ae.

...read moreread less

Abstract: Pyrethroid insecticides prolong the opening of voltage-dependent sodium channels in insect nerves to produce instant paralysis and “knock-down.” Many insects have evolved knock-down resistance through nonsynonymous mutations that reduce pyrethroid binding in the channels. In 2006 we discovered one such mutation in the arbovirus mosquito vector Aedes aegypti, called Ile1,016, that confers very high knockdown resistance to the pyrethroid insecticide permethrin in mosquitoes homozygous for this mutation. We examined collections of Ae. aegypti from Mexico during 1996–2009 and found that the overall Ile1,016 frequency increased from <0.1% in 1996–2000, to 2%–5% in 2003–2006, to 38.3%–88.3% in 2007–2009 depending upon collection location. We also demonstrate a strong linear relationship between the frequency of Ile1,016 homozygotes and knockdown rate in bioassays and speculate that widespread use of permethrin-based insecticides in Mexico may be impacting the frequency of Ile1,016. Such a rapid increase is predicted by a simple model of positive directional selection acting on a recessive allele. Unfortunately this model also predicts rapid fixation of Ile1,016 unless there is a negative fitness associated with Ile1,016 in the absence of permethrin and if insecticidal pressure can be reduced.

...read moreread less

139 citations

Journal Article•DOI•

Epidemiological Scenario of Dengue in Brazil.

[...]

Rafaelle Christine Gomes Fares¹, Katia P. R. Souza¹, Germán Añez¹, Maria Rios¹•Institutions (1)

Center for Biologics Evaluation and Research¹

30 Aug 2015-BioMed Research International

TL;DR: This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil.

...read moreread less

Abstract: Dengue is the most important reemerging mosquito-borne viral disease worldwide. It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes. Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil.

...read moreread less

101 citations

Cites background from "Dengue in the Americas: challenges ..."

...Meteorological conditions and seasonal variations may affect the distribution and abundance of the vector [72]....
[...]
...aegypti and consequently the sustained transmission of mosquito-borne diseases in Brazil, including the climate, high human population density in large cities, precarious socioeconomic status, and lack of infrastructure, particularly adequate sanitation [52, 72]....
[...]
...7, considerably higher than that reported during the same period in Honduras, Venezuela, Colombia, and Mexico, becoming the highest ratio in the continent [72]....
[...]

1
2
3
4
…
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21

Collapse

References

PDF

Open Access

More filters

Journal Article•DOI•

Potential effect of population and climate changes on global distribution of dengue fever: an empirical model.

[...]

Simon Hales¹, Neil de Wet, John H. Maindonald², Alistair Woodward¹•Institutions (2)

Wellington Management Company¹, Australian National University²

14 Sep 2002-The Lancet

TL;DR: Climate change is likely to increase the area of land with a climate suitable for dengue fever transmission, and that if no other contributing factors were to change, a large proportion of the human population would be put at risk.

...read moreread less

922 citations

"Dengue in the Americas: challenges ..." refers result in this paper

...Although there is an overall ratio of 45 dengue fever cases reported for every dengue hemorrhagic fever case detected, the ratio of dengue /dengue hemorrhagic fever cases reported in Brazil (468) and Costa Rica (396) is very different from those reported in Honduras (17), Venezuela (13), Colombia (10) or Mexico (7)....
[...]
...During the 1970’s, dengue swept through Colombia causing an extensive epidemic where more than half a million cases were estimated but most occurred silently for most of the period....
[...]
...During the 2000-2006 period, 85,331 dengue hemorrhagic fever cases were reported from Colombia and Venezuela (61%), while 16% of cases were from Mexico (Table 2)....
[...]
...From 1981 to 1996, 42,246 dengue hemorrhagic fever cases were reported in several countries, although 90% of these cases were from Venezuela (52%), Cuba (24%), Colombia (9%), Nicaragua (6...
[...]

Journal Article•DOI•

Effect of temperature on the vector efficiency of Aedes aegypti for dengue 2 virus.

[...]

Douglas M. Watts¹, Donald S. Burke², Bruce A. Harrison³, Richard E. Whitmire⁴, Ananda Nisalak¹ - Show less +1 more•Institutions (4)

United States Department of the Army¹, Walter Reed Army Institute of Research², Smithsonian Institution³, United States Army Medical Research Unit-Kenya⁴

01 Jan 1987-American Journal of Tropical Medicine and Hygiene

TL;DR: Temperature-induced variations in the vector efficiency of Ae.

...read moreread less

Abstract: The effect of temperature on the ability of Aedes aegypti to transmit dengue (DEN) 2 virus to rhesus monkeys was assessed as a possible explanation for the seasonal variation in the incidence of dengue hemorrhagic fever in Bangkok, Thailand. In two laboratory experiments, a Bangkok strain of Ae. aegypti was allowed to feed upon viremic monkeys infected with DEN-2 virus. Blood-engorged mosquitoes were separated into two groups and retained at constant temperatures. Virus infection and transmission rates were determined for Ae. aegypti at intervals ranging from 4 to 7 days during a 25-day incubation period. Results of the first experiment for mosquitoes infected with a low dose of DEN-2 virus and maintained at 20,24,26, and 3O"C, indicated that the infection rate ranged from 25% to 75% depending on the incubation period. However, DEN-2 virus was transmitted to monkeys only by Ae. aegypti retained at 30°C for 25 days. In the second experiment, the infection rate for Ae. aegypti that ingested a higher viral dose, and incubated at 26, 30, 32, and 35°C ranged from 67% to 95%. DEN-2 virus was transmitted to monkeys only by mosquitoes maintained at L 30°C. The extrinsic incubation period was 12 days for mos- quitoes at 3O"C, and was reduced to 7 days for mosquitoes incubated at 32°C and 35°C. These results imply that temperature-induced variations in the vector efficiency of Ae. aegypti may be a significant determinant in the annual cyclic pattern of dengue hemorrhagic fever epidemics in-Bangkok.

...read moreread less

709 citations

"Dengue in the Americas: challenges ..." refers result in this paper

...Although there is an overall ratio of 45 dengue fever cases reported for every dengue hemorrhagic fever case detected, the ratio of dengue /dengue hemorrhagic fever cases reported in Brazil (468) and Costa Rica (396) is very different from those reported in Honduras (17), Venezuela (13), Colombia (10) or Mexico (7)....
[...]
...During the 2000-2006 period, 85,331 dengue hemorrhagic fever cases were reported from Colombia and Venezuela (61%), while 16% of cases were from Mexico (Table 2)....
[...]
...From 1981 to 1996, 42,246 dengue hemorrhagic fever cases were reported in several countries, although 90% of these cases were from Venezuela (52%), Cuba (24%), Colombia (9%), Nicaragua (6...
[...]
...Kroeger A, Lenhart A, Ochoa M, Villegas E, Levy M, Alexander N, et al. Effective control of dengue vectors with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomised trials....
[...]
...Cases in Cuba and Venezuela include all age groups, although two thirds of the fatalities have been in children under the age of 15....
[...]

Journal Article•DOI•

Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas.

[...]

Rebeca Rico-Hesse¹, Lisa M. Harrison¹, Rosa Alba Salas², Duilia Tovar², Ananda Nisalak, Celso Ramos, Jorge Boshell, Maria Teresa R. de Mesa³, Rita Maria Ribeiro Nogueira⁴, Amelia P.A. Travassos Da Rosa - Show less +6 more•Institutions (4)

Yale University¹, Rafael Advanced Defense Systems², University of Valle³, Oswaldo Cruz Foundation⁴

14 Apr 1997-Virology

TL;DR: Phylogenetic analyses suggest that these genotypes of dengue type 2 virus originated in Southeast Asia and that they displaced the native, American genotype in at least four countries, and vaccination and other control efforts should therefore be directed at decreasing the transmission of these "virulent" genotypes.

...read moreread less

676 citations

Journal Article•DOI•

Dengue/dengue hemorrhagic fever: the emergence of a global health problem.

[...]

Duane J. Gubler¹, Gary G. Clark•Institutions (1)

Centers for Disease Control and Prevention¹

01 Apr 1995-Emerging Infectious Diseases

TL;DR: The near simultaneous occurrence of outbreaks of dengue fever on three continents indicates that these viruses and their mosquito vector have had a worldwide distribution in the tropics for more than 200 years.

...read moreread less

Abstract: Dengue and dengue hemorrhagic fever (DHF) are caused by one of four closely related but antigenically distinct virus serotypes (DEN-1 DEN-2 DEN- 3 and DEN-4) of the genus Flavivirus. Infection with one of these serotypes does not provide cross-protective immunity so persons living in a dengueendemic area can have four dengue infections during their lifetimes. Dengue is primarily an urban disease of the tropics and the viruses that cause it are maintained in a cycle that involves humans and Aedes aegypti a domestic day-biting mosquito that prefers to feed on humans. Infection with a dengue virus serotype can produce a spectrum of clinical illness ranging from a nonspecific viral syndrome to severe and fatal hemorrhagic disease. Important risk factors for DHF include the strain and serotype of the virus involved as well as the age immune status and genetic predisposition of the patient. The first reported epidemics of dengue fever occurred in 1779-1780 in Asia Africa and North America; the near simultaneous occurrence of outbreaks on three continents indicates that these viruses and their mosquito vector have had a worldwide distribution in the tropics for more than 200 years. During most of this time dengue fever was considered a benign nonfatal disease of visitors to the tropics. Generally there were long intervals (10-40 years) between major epidemics mainly because the viruses and their mosquito vector could only be transported between population centers by sailing vessels. (excerpt)

...read moreread less

666 citations

Journal Article•DOI•

Molecular evolution and distribution of dengue viruses type 1 and 2 in nature.

[...]

Rebeca Rico-Hesse¹•Institutions (1)

Yale University¹

01 Feb 1990-Virology

TL;DR: This work reports the first genetic evidence of the existence of a sylvatic cycle of dengue virus, which is clearly distinct from outbreak viruses, which seems to have evolved independently in West Africa.

...read moreread less

579 citations