Deposition of Ultrafine (NANO) Particles in the Human Lung
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...It has been observed that ultrafine particles with diameters <100 nm deposits in all regions, whereas particles <10 nm deposits in the tracheobronchial region, while particles between 10 and 20 nm deposits in the alveolar region [27]....
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284 citations
Cites background from "Deposition of Ultrafine (NANO) Part..."
...As summarized elsewhere (7, 107), inhaled particles of different sizes exhibit different fractional depositions within the human respiratory tract....
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...Although inhaled ultrafine particles ( 100 nm) deposit in all regions, tracheobronchial deposition is highest for particles 10 nm in size, whereas alveolar deposition is highest for particles approximately 10–20 nm in size (7, 107)....
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References
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"Deposition of Ultrafine (NANO) Part..." refers background in this paper
...Convective mixing has often been assumed to be diffusive in nature, propagating by dispersion (Darquenne et al., 1997; Edwards, 1994; Egan et al., 1989; Hofmann et al., 1994; Taulbee & Yu, 1975)....
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...(2) and other similar equations have been extended to particles (Darquenne & Paiva, 1994; Hofmann et al., 1994; Taulbee & Yu, 1978) despite being specifically developed for gases....
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1,290 citations
"Deposition of Ultrafine (NANO) Part..." refers background in this paper
...Exposure to nanoparticles can exacerbate respiratory disease (Peters et al., 1997) and produces toxicity even at low concentrations (Johnston et al., 2000)....
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1,002 citations
"Deposition of Ultrafine (NANO) Part..." refers background or methods in this paper
...…were made for particles between 5 nm and 100 nm. Figure 7 A and B, shows the comparison of predicted total deposition fraction against measurements of Heyder et al. (1986), Jaques and Kim (2000), Schiller et al. (1988), and Tu and Knudson (1984) in the SBAN and LBAN stochastic lungs, respectively....
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...The agreement with Heyder et al. (1986) and Tu and Knudson is excellent, while comparison with the measurements of Schiller et al. (1988) shows some scatter around the line of identity for the SBAN stochastic lung....
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767 citations
"Deposition of Ultrafine (NANO) Part..." refers background in this paper
...Due to their physicochemical characteristics that give them enhanced properties (Maynard et al., 2004), manufactured nanoparticles may be biopersistant and remain intact and cause toxicity....
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713 citations
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...E-mail: Asgharian@thehamner.org related to the ultrafine, nanosized fraction of the products (Ferin & Oberdörster, 1992; Oberdörster et al., 1992)....
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