Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis
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TLDR
The relationship between depression and HIV treatment nonadherence is consistent across samples and over time, is not limited to those with clinical depression, and is not inflated by self-report bias.Abstract:
We meta-analyzed the relationship between depression and HIV medication nonadherence to calculate the overall effect size and examine potential moderators. Overall, across 95 independent samples, depression was significantly (P < 0.0001) associated with nonadherence (r = 0.19; 95% confidence interval = 0.14 to 0.25). Studies evaluating medication adherence via interview found significantly larger effects than those using self-administered questionnaires. Studies measuring adherence along a continuum found significantly stronger effects than studies comparing dichotomies. Effect size was not significantly related to other aspects of adherence or depression measurement, assessment interval (ie, cross-sectional vs. longitudinal), sex, IV drug use, sexual orientation, or study location. The relationship between depression and HIV treatment nonadherence is consistent across samples and over time, is not limited to those with clinical depression, and is not inflated by self-report bias. Our results suggest that interventions aimed at reducing depressive symptom severity, even at subclinical levels, should be a behavioral research priority.read more
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Journal ArticleDOI
Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.
Melanie A. Thompson,Michael J. Mugavero,K. Rivet Amico,Victoria A. Cargill,Larry W. Chang,Robert E. Gross,Catherine Orrell,Frederick L. Altice,David R. Bangsberg,John G. Bartlett,Curt G. Beckwith,Nadia Dowshen,Christopher M. Gordon,Tim Horn,Princy Kumar,James D. Scott,Michael J. Stirratt,Robert H. Remien,Jane M. Simoni,Jean B. Nachega +19 more
TL;DR: Recommendations cover ART strategies, adherence tools, education and counseling, and health system and service delivery interventions that cover specific issues pertaining to pregnant women, incarcerated individuals, homeless and marginally housed individuals, and children and adolescents, as well as substance use and mental health disorders.
Journal ArticleDOI
Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis
Nienke Langebeek,Elisabeth H. Gisolf,Peter Reiss,Sigrid C. J. M. Vervoort,Thóra B. Hafsteinsdóttir,Clemens Richter,Mirjam A. G. Sprangers,Pythia T. Nieuwkerk +7 more
TL;DR: Findings suggest that adherence-enhancing interventions should particularly target psychological factors such as self-efficacy and concerns/beliefs about the efficacy and safety of ART, and that simplification of regimens might have smaller but significant effects.
Journal ArticleDOI
Depression and Adherence to Antiretroviral Therapy in Low-, Middle- and High-Income Countries: A Systematic Review and Meta-Analysis
Olalekan A. Uthman,Jessica F. Magidson,Steven A. Safren,Jean B. Nachega,Jean B. Nachega,Jean B. Nachega +5 more
TL;DR: The magnitude of the association significantly decreases with more recent publications and increasing study sample size, and the likelihood of achieving good adherence to ART was lower among those with depressive symptoms compared to those without.
Journal ArticleDOI
Mental health and HIV/AIDS: The need for an integrated response
Robert H. Remien,Michael J. Stirratt,Nadia Nguyen,Reuben N. Robbins,Andrea Norcini Pala,Claude A. Mellins +5 more
TL;DR: In this paper, the authors address the significant mental health and substance use problems among people living with HIV (PLWH) and people vulnerable to acquiring HIV (PVC) and highlight the need to prioritize mental health treatment with appropriate resources to address the current mental health screening and treatment gaps.
Journal ArticleDOI
Depression Treatment Enhances Adherence to Antiretroviral Therapy: a Meta-Analysis
TL;DR: Findings support the need for detection and treatment of depression among persons living with HIV/AIDS and improve antiretroviral adherence.
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