Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress.
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TLDR
It is suggested that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CAMKIV, CREB, and BDNF levels in specific brain areas, leading to oxidative stress-induced anxiety-depression-like behaviors and as well as memory impairment in rats.About:
This article is published in Brain Research.The article was published on 2013-11-20 and is currently open access. It has received 314 citations till now. The article focuses on the topics: Social defeat & Social stress.read more
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Journal ArticleDOI
Oxidative Stress and the Central Nervous System.
TL;DR: This review is a discussion of the relevance of cerebral oxidative stress to impairment of emotional and mental well-being in neuropsychiatric disorders, including anxiety disorders and depression.
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Obesity and neuroinflammation: a pathway to cognitive impairment.
TL;DR: The evidence that obesity and high fat feeding can lead to cognitive dysfunction is addressed and the idea that obesity-associated systemic inflammation leads to inflammation within the brain, particularly the hypothalamus, and that this is partially responsible for negative cognitive outcomes is examined.
Journal ArticleDOI
Oxidative Stress and Psychological Disorders
TL;DR: A review examines some of the recent discoveries that link oxidative status with anxiety, depression, schizophrenia and bipolar disorder and published results and questions regarding a causal relationship between oxidative and emotional stress.
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The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study.
Melinda C. Power,Melinda C. Power,Marianthi-Anna Kioumourtzoglou,Jaime E. Hart,Olivia I. Okereke,Francine Laden,Marc G. Weisskopf +6 more
TL;DR: Exposure to fine particulate matter (PM2.5) was associated with high symptoms of anxiety, with more recent exposures potentially more relevant than more distant exposures.
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Neurobiological effects of exercise on major depressive disorder: A systematic review.
Felipe Barreto Schuch,Andrea Camaz Deslandes,Brendon Stubbs,Natan Pereira Gosmann,Cristiano Tschiedel Belem da Silva,Marcelo Pio de Almeida Fleck +5 more
TL;DR: A systematic review of the acute and chronic biological responses to exercise in people with major depressive disorder found associations between depressive symptoms improvement and hippocampus volume and IL-1β were found, but the paucity of studies and limitations presented within precludes a more definitive conclusion.
References
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Journal ArticleDOI
Stress, social support, and the buffering hypothesis.
Sheldon Cohen,Thomas Ashby Wills +1 more
TL;DR: There is evidence consistent with both main effect and main effect models for social support, but each represents a different process through which social support may affect well-being.
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Oxidative stress: oxidants and antioxidants
TL;DR: These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’.
Journal ArticleDOI
Psychological Stress and Disease
TL;DR: The plausibility of the belief that stress contributes to a variety of disease processes is discussed and the role of stress in 4 major diseases: clinical depression, cardiovascular disease, human immunodeficiency virus/AIDS, and cancer is summarized.
Journal ArticleDOI
Stress signalling pathways that impair prefrontal cortex structure and function
TL;DR: Recent research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.
Journal ArticleDOI
Oxidative stress hypothesis in alzheimer's disease
TL;DR: Supporting indirect evidence comes from a variety of in vitro studies showing that free radicals are capable of mediating neuron degeneration and death, suggesting that therapeutic efforts aimed at removal of ROS or prevention of their formation may be beneficial in AD.
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