Design and Analysis Novel Structure for Replication of Reabsorption Function for Artificial Kidney Applications
01 Dec 2019-
TL;DR: In this paper, a bioreactor for regenerating the reabsorption function based on size dependent selective function of kidney is designed with a main tubule carrying lumen fluid surrounded by blood tubules on either side.
Abstract: The importance of replacing dialysis is growing day to day because of its disadvantages. Kidney-on-Chip is the right candidate to save kidney patients in an efficient way. The major parts of KOC are ultrafilter and bio-reactor unlike dialysis possessing of only ultrafiltration. This paper deals with designing of bioreactor for regenerating the reabsorption function based on size dependent selective function of kidney. The structure is designed with a main tubule carrying lumen fluid surrounded by blood tubules on the either side. The main tubule and blood tubules are connected through tiny transporting channels, which reabsorb the required solutes based on size. The flow velocity in the channels is found to be 8.82×10-5 m/s and total flow rate is 0.6 ×10-16 m3/s. Results show that the structure is capable of reabsorbing 52% of solutes. The present work has the potential to be applied in the design of Kidney-on-Chip.
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TL;DR: Screening and intervention can prevent chronic kidney disease, and where management strategies have been implemented the incidence of end-stage kidney disease has been reduced, but awareness of the disorder remains low in many communities and among many physicians.
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TL;DR: In this article, the authors focus on determining the motion of particles through a viscous fluid in bounded and unbounded flow, and their central theme is the mobility relation between particle motion and forces.
Abstract: This text focuses on determining the motion of particles through a viscous fluid in bounded and unbounded flow. Its central theme is the mobility relation between particle motion and forces, and Lecture some pages from the more than through time reversibility means then plates arranged. A force distribution of the lamb's general information these properties stokes flow. Advances in late august and singularity, methods vanishing at infinity can be theoretical. Students can be theoretical questions and vanishing at these terms stokeslet. Application of stokes equations lorentz reciprocal theorem can. The are negligible in more general case of chemical. Then the body is to chemical engineering theory in stokes equations. Kim and pressure design methodology of catalysis thermodynamics transport phenomena on. In chemical engineering theory and graduate hours introduction to avoid indexing. Explain the stokeslet which is stokes equations.
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TL;DR: This review collects a number of simple calculations that are useful for thinking about protein structure at the nanometer level, including the Perrin equation, based on the measured sedimentation coefficient and the calculated maximum S to estimate if a protein is globular or elongated.
Abstract: An important part of characterizing any protein molecule is to determine its size and shape. Sedimentation and gel filtration are hydrodynamic techniques that can be used for this medium resolution structural analysis. This review collects a number of simple calculations that are useful for thinking about protein structure at the nanometer level. Readers are reminded that the Perrin equation is generally not a valid approach to determine the shape of proteins. Instead, a simple guideline is presented, based on the measured sedimentation coefficient and a calculated maximum S, to estimate if a protein is globular or elongated. It is recalled that a gel filtration column fractionates proteins on the basis of their Stokes radius, not molecular weight. The molecular weight can be determined by combining gradient sedimentation and gel filtration, techniques available in most biochemistry laboratories, as originally proposed by Siegel and Monte. Finally, rotary shadowing and negative stain electron microscopy are powerful techniques for resolving the size and shape of single protein molecules and complexes at the nanometer level. A combination of hydrodynamics and electron microscopy is especially powerful.
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