Journal ArticleDOI
Design and development of polymeric micelles with cleavable links for intracellular drug delivery
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TLDR
This review highlights the recent advance in this field and focuses on two types of polymeric micelles that can respond to the physiological signals, i.e., intracellular pH- and reduction-sensitive micells.About:
This article is published in Progress in Polymer Science.The article was published on 2013-03-01. It has received 437 citations till now.read more
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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
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Nanotechnology for Multimodal Synergistic Cancer Therapy
TL;DR: In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergy therapy.
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Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future
Jiong Zhou,Guocan Yu,Feihe Huang +2 more
TL;DR: A review summarizing the progress of supramolecular chemotherapy in cancer treatment based on host-guest recognition and guidance on the design of new targeting supramolescular chemotherapy combining diagnostic and therapeutic functions is presented.
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Redox-responsive polymers for drug delivery: from molecular design to applications
TL;DR: This review discusses the reduction- and oxidation-responsive polymeric drug carriers from the view of functional groups, as well as their applications in controlled release.
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Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer
TL;DR: The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies.
References
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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.
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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
TL;DR: Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.
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The resurgence of platinum-based cancer chemotherapy
TL;DR: Key developments include the elucidation of mechanisms of tumour resistance to these drugs, the introduction of new platinum-based agents (oxaliplatin, satraplatin and picoplatin), and clinical combination studies using platinum drugs with resistance modulators or new molecularly targeted drugs.
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Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
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Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.