Book ChapterDOI
Design of a Mixer for Performing Efficient Mixing to Reduce Overall Assay Response Time
Debasis Dhal,Piyali Datta,Arpan Chakraborty,Rajat Kumar Pal +3 more
- pp 559-568
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TLDR
The effects of varying mixer sizes are studied and the proposed of mixing strategies applicable to some Polymerase Chain Reaction (PCR) where a series of mixing is required.Abstract:
Digital Microfluidic Biochip (DMFB) is revolutionizing many areas of Microelectronics, Biochemistry, and Biomedical sciences. It is also known as ‘Lab-on-a-Chip’ for its popularity as an alternative for laboratory experiments. The mixing of samples and reagents for a biological or chemical lab-on-a-chip is important, yet difficult, in microfluidic operations. As volume is of the order of sub-nanoliter, the mixing of liquids is hindered by laminar flow conditions. The fixed geometric parameters of the mixer and the type of movement of the coalesced droplet control droplet mixing time. In this paper, we study the effects of varying mixer sizes and propose of mixing strategies applicable to some Polymerase Chain Reaction (PCR) where a series of mixing is required. A design of mixer has been proposed including its pin assignment where reduction of time of mixing is a key challenging issue to enhance the performance of the chip in terms of throughput.read more
References
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Journal ArticleDOI
Digital microfluidics: is a true lab-on-a-chip possible?
TL;DR: To understand the opportunities and limitations of EWD microfluidics, this paper looks at the development of lab-on-chip applications in a hierarchical approach.
Journal ArticleDOI
Rapid droplet mixers for digital microfluidic systems.
TL;DR: This paper studies the effects of varying droplet aspect ratios on linear-array droplet mixers, and proposes mixing strategies applicable for both high and low aspect ratio systems, and presents a split-and-merge mixer that takes advantage of the ability to perform droplet splitting at these ratios.
Journal ArticleDOI
Electrowetting-based droplet mixers for microfluidic systems
TL;DR: In this paper, an alternative mixing strategy is presented based on the discretization of liquids into droplets and further manipulation of those droplets by electrowetting, where interfacial tensions of the droplets are controlled with the application of voltage.
Proceedings ArticleDOI
Electrowetting-based on-chip sample processing for integrated microfluidics
Richard B. Fair,Vijay Srinivasan,Hong Ren,Philip Y. Paik,Vamsee K. Pamula,Michael G. Pollack +5 more
TL;DR: In this article, results and data are reported on key aspects of sample processing protocols performed on-chip in a digital microfluidic lab on-a-chip (LABON-A-chip).
Proceedings ArticleDOI
Droplet-trace-based array partitioning and a pin assignment algorithm for the automated design of digital microfluidic biochips
Tao Xu,Krishnendu Chakrabarty +1 more
TL;DR: A partitioning algorithm based on the concept of "droplet trace", which is extracted from the scheduling and droplet routing results produced by a synthesis tool, is proposed and an efficient pin assignment method, referred to as the "Connect-5 algorithm", is combined with the array partitioning technique based on droplet traces.