Design Optimization at the Fluid-Level Synthesis for Safe and Low-Cost Droplet-Based Microfluidic Biochips
TL;DR: A fluid-level design for DMFBs is proposed that is capable of handling reliability and also free from cross contamination, and a graph model has been used to tackle them.
Abstract: Droplet-based Digital Microfluidic Biochips (or DMFBs) are now being the prime platform for a number of point of care diagnostics, clinical studies, and sample preparations. Several design optimization methods exist at the fluid-level that automate the tasks of a DMFB. However, in high frequency applications, its performance heavily deteriorates in the order of degrading electrodes producing incorrect outcomes. Vague results may also be generated if cross contamination during droplet routing is not avoided. We define a DMFB to be safe if it is capable of handling reliability and also free from cross contamination. Alongside, as the fluid-level of DMFBs comprises several tasks that altogether introduces design cycles and leads to higher cost, a low-cost platform is urgently required. This paper proposes a fluid-level design for DMFBs that considers the above facts together. A graph model has been used to tackle them. An exact algorithm is presented. The obtained results are validated with several benchmarks.
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Citations
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Cites methods from "Design Optimization at the Fluid-Le..."
...The authors of [22] proposed a fluid-level design for DMFBs that considered cross-contamination and degrading electrodes together, and a graph model was used to address them....
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Cites methods from "Design Optimization at the Fluid-Le..."
...The design process of the DMFBs consist of binding, scheduling, placement, and routing tasks [6-8]....
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References
168 citations
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98 citations
"Design Optimization at the Fluid-Le..." refers background or methods in this paper
...Following [8], an edge disjoint path connecting the modules is found out....
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...Each sub-problem is solved in order to get a contamination free routing by reduction from disjoint-path (either vertex or edge disjoint) problem [8]....
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73 citations
"Design Optimization at the Fluid-Le..." refers background in this paper
...binding, scheduling, placement, and routing tasks from the input bioassay graph together with the chip architecture and design specification [4], [5]....
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73 citations
59 citations
"Design Optimization at the Fluid-Le..." refers background in this paper
...A considerable amount of researches have been made to avoid cross contamination at the routing phase [8], [11]....
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