Design Strategies and Applications of Tissue Bioadhesives
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TLDR
This paper focuses on existing tissue adhesive design, their structure, functioning mechanism, and their pros and cons in wound management and includes the latest advances in the development of new tissue adhesives as well as the emerging applications in regenerative medicine.Abstract:
In the past two decades tissue adhesives and sealants have revolutionized bleeding control and wound healing. This paper focuses on existing tissue adhesive design, their structure, functioning mechanism, and their pros and cons in wound management. It also includes the latest advances in the development of new tissue adhesives as well as the emerging applications in regenerative medicine. We expect that this paper will provide insightful discussion on tissue bioadhesive design and lead to innovations for the development of the next generation of tissue bioadhesives and their related biomedical applications.read more
Citations
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Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein
TL;DR: Recent findings on the contributions of various features of Mfps on interfacial binding, which include coacervate formation, surface drying properties, control of the oxidation state of catechol, among other features are reviewed.
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Hydrogel Adhesion: A Supramolecular Synergy of Chemistry, Topology, and Mechanics
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Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing
Nasim Annabi,Nasim Annabi,Nasim Annabi,Devyesh Rana,Ehsan Shirzaei Sani,Roberto Portillo-Lara,Jessie L. Gifford,Mohammad M. Fares,Suzanne M. Mithieux,Anthony S. Weiss +9 more
TL;DR: A new sprayable, elastic, and biocompatible composite hydrogel, with broad-spectrum antimicrobial activity, for the treatment of chronic wounds is reported, engineered using two ECM-derived biopolymers and the antimicrobial peptide Tet213.
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The chemistry of tissue adhesive materials
Petra J. M. Bouten,Petra J. M. Bouten,Marleen Zonjee,Johan C. M. E. Bender,Simon T.K. Yauw,Harry van Goor,Jan C. M. van Hest,Richard Hoogenboom +7 more
TL;DR: This review provides an overview of tissue adhesive materials from a polymer chemistry perspective and is intended as starting point and inspiration for these future research efforts to develop the next generation tissue adhesives.
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Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding.
TL;DR: A comprehensive review regarding the various topical, intracavitary, and intravenous hemostatic technologies in terms of materials, mechanisms, and state‐of‐art is provided, and challenges and opportunities to help advancement of the field are discussed.
References
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology†
TL;DR: This work highlights recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for biomedical and biological applications and shows how such systems' intelligent behavior can be used in sensors, microarrays, and imaging.
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A reversible wet/dry adhesive inspired by mussels and geckos
TL;DR: A hybrid biologically inspired adhesive consisting of an array of nanofabricated polymer pillars coated with a thin layer of a synthetic polymer that mimics the wet adhesive proteins found in mussel holdfasts is reported, useful for reversible attachment to a variety of surfaces in any environment.
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Microfabricated adhesive mimicking gecko foot-hair.
Andre K. Geim,S. V. Dubonos,Irina V. Grigorieva,Kostya S. Novoselov,Andrey A. Zhukov,S. Yu. Shapoval +5 more
TL;DR: A prototype of such 'gecko tape' is reported on, made by microfabrication of dense arrays of flexible plastic pillars, the geometry of which is optimized to ensure their collective adhesion.
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Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.
Dong-An Wang,Dong-An Wang,Shyni Varghese,Blanka Sharma,Iossif Strehin,Sara Fermanian,Justin M. Gorham,D. Howard Fairbrother,Brett M. Cascio,Jennifer H. Elisseeff +9 more
TL;DR: The biopolymer chondroitin sulphate, one of the major components of cartilage extracellular matrix, is used to develop a novel bioadhesive that is readily applied and acts quickly and led to mechanical stability of the hydrogel and tissue repair in cartilage defects.