Journal ArticleDOI
Designing an efficient multi-epitope vaccine against Campylobacter jejuni using immunoinformatics and reverse vaccinology approach
Nayan Gupta,Ajay Kumar +1 more
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TLDR
The Reverse vaccinology approach was used to identify vaccine targets from the proteome of diarrheagenic C. jejuni strain NCTC11168 for the development of chimeric vaccine candidates against C.jejuni, and pathogen proteins that have adhesin like properties but not present in the human host were selected for the design of a multi-epitope vaccine.About:
This article is published in Microbial Pathogenesis.The article was published on 2020-08-06. It has received 17 citations till now. The article focuses on the topics: Reverse vaccinology.read more
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Pan-vaccinomics approach towards a universal vaccine candidate against WHO priority pathogens to address growing global antibiotic resistance.
Saba Ismail,Farah Shahid,Abbas Khan,Sadia Bhatti,Sajjad Ahmad,Anam Naz,Ahmad Almatroudi,Muhammad Tahir ul Qamar +7 more
TL;DR: In this article, the authors used pan-genomics, subtractive proteomics, reverse vaccinology, immunoinformatics, molecular docking and dynamics simulation studies to identify a universal potential vaccine candidate against the 18 multi-drug resistance (MDRs) bacterial pathogenic species from a WHO priority list.
Journal ArticleDOI
Designing a Recombinant Vaccine against Providencia rettgeri Using Immunoinformatics Approach
Saba Gul,Sajjad Ahmad,Asad Ullah,Saba Ismail,Muhammad Khurram,Muhammad Tahir ul Qamar,Abdulrahim R. Hakami,Ali G. Alkhathami,Faris Alrumaihi,Khaled S Allemailem +9 more
TL;DR: Findings of the current study are promising and may help experimental vaccinologists to formulate a novel multi-epitope vaccine against P. rettgeri, a major cause of traveler’s diarrhea.
Journal ArticleDOI
Designing of a Recombinant Multi-Epitopes Based Vaccine against Enterococcus mundtii Using Bioinformatics and Immunoinformatics Approaches
Metab Alharbi,Abdulrahman Alshammari,A. Alasmari,Salman Mansour Alharbi,Muhammad Tahir ul Qamar,Asad Ullah,Sajjad Ahmad,Muhammad Irfan,Atif A Khalil +8 more
TL;DR: A multi-epitope-based vaccine against E. mundtii is designed using in silico approaches and blind docking with immune cell receptors, followed by molecular dynamic simulation results confirms the good binding potency and stability of the vaccine in providing protection against the pathogen.
Journal ArticleDOI
A Vaccine Construction against COVID-19-Associated Mucormycosis Contrived with Immunoinformatics-Based Scavenging of Potential Mucoralean Epitopes
Muhammad Naveed,Urooj Ali,Mohmed Isaqali Karobari,Naveed Ahmed,Roshan Noor Mohamed,Shahabe Saquib Abullais,Md. Abdul Kader,Anand Marya,Pietro Messina,Giuseppe Alessandro Scardina +9 more
TL;DR: A potential vaccine construct targeting mucor and rhizopus species responsible for mucormycosis infections, providing immunoprotection to immunocompromised patients and may contribute to minimizing postdiagnostic burdens and failures is proposed.
Journal ArticleDOI
Cellulolytic bacterium characterization and genome functional analysis: An attempt to lay the foundation for waste management
Xuejiao An,Xi Chen,Yue Wang,Xinyue Zhao,Xiaoshuang Xiao,Haozhi Long,Hanguang Li,Qinghua Zhang +7 more
TL;DR: The genetic basis of strain AXJ-M for efficient degradation of cellulose was identified and mRNA expression indicated that GH1, GH3 and GH8 might determine the strain's cellulose degradation ability.
References
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Journal ArticleDOI
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Stephen F. Altschul,Thomas L. Madden,Alejandro A. Schäffer,Jinghui Zhang,Zheng Zhang,Webb Miller,David J. Lipman +6 more
TL;DR: A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original.
Journal ArticleDOI
Scalable molecular dynamics with NAMD
James C. Phillips,Rosemary Braun,Wei Wang,James C. Gumbart,Emad Tajkhorshid,Elizabeth Villa,Christophe Chipot,Robert D. Skeel,Laxmikant V. Kale,Klaus Schulten +9 more
TL;DR: NAMD as discussed by the authors is a parallel molecular dynamics code designed for high-performance simulation of large biomolecular systems that scales to hundreds of processors on high-end parallel platforms, as well as tens of processors in low-cost commodity clusters, and also runs on individual desktop and laptop computers.
Book ChapterDOI
Protein identification and analysis tools in the ExPASy server
Marc R. Wilkins,Elisabeth Gasteiger,Amos Marc Bairoch,Jean Emmanuel Sanchez,Keith L. Williams,Ron D. Appel,Denis Hochstrasser +6 more
TL;DR: Details are given about protein identification and analysis software that is available through the ExPASy World Wide Web server and the extensive annotation available in the Swiss-Prot database is used.
Journal ArticleDOI
The Phyre2 web portal for protein modeling, prediction and analysis
Lawrence A. Kelley,Stefans Mezulis,Christopher M. Yates,Christopher M. Yates,Mark N. Wass,Mark N. Wass,Michael J.E. Sternberg +6 more
TL;DR: An updated protocol for Phyre2, which uses advanced remote homology detection methods to build 3D models, predict ligand binding sites and analyze the effect of amino acid variants for a user's protein sequence.