Journal ArticleDOI
Designing an ESIPT-based fluorescent probe for imaging of hydrogen peroxide during the ferroptosis process.
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TLDR
An excited-state intramolecular proton transfer (ESIPT)-based probe BTFMB was developed and successfully applied for monitoring exogenous and endogenous production of H2O2, and identifying accumulation of H 2O2 during the ferroptosis process.About:
This article is published in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.The article was published on 2021-03-05. It has received 32 citations till now.read more
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Journal ArticleDOI
Recent advances in small-molecule fluorescent probes for studying ferroptosis.
TL;DR: This review comprehensively reviewed the recent development of small-molecule fluorescent probes for studying ferroptosis with a focus on the analytes, design strategies and bioimaging applications and provided new insights to overcome the major challenges in this emerging field.
Journal ArticleDOI
Fluorescent Benzothiadiazole Derivatives as Fluorescence Imaging Dyes: A Decade of New Generation Probes.
TL;DR: A review of the use of fluorescent 2,1,3-benzothiadiazole (BTD) derivatives in bioimaging is presented in this paper, where the authors describe the application of BTD-containing fluorophores applied as, inter alia, bioprobes for imaging cell nuclei, mitochondria, lipid droplets, sensors, markers for proteins and related events, biological processes and activities, lysosomes, plasma membranes, multicellular models and animals.
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A biotin-guided two-photon fluorescent probe for detection of hydrogen peroxide in cancer cells ferroptosis process.
TL;DR: Li et al. as mentioned in this paper developed a biotin-guided two-photon fluorescent probe (BT-HP) for sensitive detection of H2O2 in cancer cells, which can selectively enter cancer cells and perform fluorescence imaging of the hydrogen peroxide in the cancer cells.
Journal ArticleDOI
A NIR fluorescent probe for the in vitro and in vivo selective detection of hydrogen peroxide
TL;DR: The construction of a turn-on fluorescent probe, TMN-H2O2 with near-infrared emission with excellent sensitivity and fast response time is reported, suggesting that this probe is a reliable chemical tool for monitoring both endogenous and exogenous H2 O2.
Journal ArticleDOI
NIR Fluorescent Probe for In Situ Bioimaging of Endogenous H2S in Rice Roots under Al3+ and Flooding Stresses.
TL;DR: In this article, a NIR fluorescent probe (HBTP-H2S) was synthesized to achieve H2S imaging in living plant tissues and used to detect the fluctuation of endogenous hydrogen sulfide levels in response to physiological stimulations.
References
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Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
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Neurodegenerative diseases and oxidative stress.
TL;DR: Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and different strategies, including novel metal–protein attenuating compounds aimed at a variety of targets have shown promise in clinical studies.
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Cellular defenses against damage from reactive oxygen species
TL;DR: Ceruloplasmin should appear as follows: [See PDF]
Journal ArticleDOI
Reactive oxygen species produced by nadph oxidase regulate plant cell growth
Julia Foreman,Vadim Demidchik,John H. F. Bothwell,Panagiota Mylona,Henk Miedema,Miguel Angel Torres,Miguel Angel Torres,Paul Linstead,Silvia Costa,Colin Brownlee,Jonathan D. G. Jones,Julia M. Davies,Liam Dolan +12 more
TL;DR: It is shown here that RHD2 is an NADPH oxidase, a protein that transfers electrons from NADPH to an electron acceptor leading to the formation of reactive oxygen species (ROS) and that ROS accumulate in growing wild-type (WT) root hairs but their levels are markedly decreased in rhd2 mutants.
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Reconciling the chemistry and biology of reactive oxygen species
TL;DR: This review examines how target selectivity and antioxidant effectiveness vary for different oxidants and highlights areas where greater understanding is required on the fate of oxidants generated by cellular NADPH oxidases and on the identification of oxidant sensors in cell signaling.