Journal ArticleDOI
Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints
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TLDR
The state-of-the-art knowledge concerning the protective and destructive roles of host inflammatory immune response will be critically evaluated and discussed from the tissue destruction and control- of-infection viewpoints.Abstract:
Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the destruction of tooth-supporting structures, being the presence of periodontopathogens required, but not sufficient, for disease development. As a general rule, host inflammatory mediators have been associated with tissue destruction, while anti-inflammatory mediators counteract and attenuate disease progression. With the discovery of several T-cell subsets bearing distinct immunoregulatory properties, this pro- vs. anti-inflammatory scenario became more complex, and a series of studies has hypothesized protective or destructive roles for Th1, Th2, Th17, and Treg subpopulations of polarized lymphocytes. Interestingly, the “protective vs. destructive” archetype is usually considered in a framework related to tissue destruction and disease progression. However, it is important to remember that periodontal diseases are infectious inflammatory conditions, and recent studies have demonstrated that cytokines (TNF-α and IF...read more
Citations
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Journal ArticleDOI
Inflammatory and immune pathways in the pathogenesis of periodontal disease.
TL;DR: Current knowledge of the host response in periodontitis is delineated to delineate the role of innate immunity, the failure of acute inflammation to resolve (thus becoming chronic), the cytokine pathways that regulate the activation of acquired immunity and the cells and products of the immune system are considered.
Journal ArticleDOI
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response.
TL;DR: New paradigms in the understanding of periodontitis are discussed, which may shed light into other polymicrobial inflammatory disorders and highlight gaps in knowledge required for an integrated picture of the interplay between microbes and innate and adaptive immune elements that initiate and propagate chronic periodontal inflammation.
Journal ArticleDOI
Inflammatory mediators in the pathogenesis of periodontitis
Tülay Yucel-Lindberg,Tove Båge +1 more
TL;DR: This review summarises recent studies on the pathogenesis of periodontitis, with the main focus on inflammatory mediators and their role in periodontal disease.
Journal ArticleDOI
Lessons learned and unlearned in periodontal microbiology.
TL;DR: This article will review how the comprehension of the structure and function of the subgingival microbiota has evolved over the years in search of lessons learned and unlearned in periodontal microbiology and how novel systems‐biology approaches promise to unravel new details of the pathogenesis ofperiodontal diseases and hopefully lead to a better understanding of their mechanisms.
Journal ArticleDOI
Breaking bad: manipulation of the host response by Porphyromonas gingivalis.
TL;DR: In this paper, the authors present a review of established mechanisms by which Porphyromonas gingivalis interferes with host immunity and enables the emergence of dysbiotic communities.
References
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Impact of Basic Research On Tomorrow's MedicineProinflammatory Cytokines
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Journal ArticleDOI
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