Detection and analysis of mammary gland stem cells.
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...Nowadays, breast CSCs are identifi ed by one or more of the following features: their ability to form tumours in vivo; mammosphere formation in vitro; expression of aldehyde dehydrogenase; or through expression of cell surface biomarkers, usually the CD44+/CD24–/low phenotype [30]....
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1,091 citations
Cites background from "Detection and analysis of mammary g..."
...The human mammary gland contains at least three distinct epithelial cell types: luminal cells (CD44CD49fCD24ESA), basal/myoepithelial cells (CD44CD49fCD24 ESA), and bipotent progenitor/stem cells (CD44CD24ESA) (10, 16)....
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788 citations
Cites background from "Detection and analysis of mammary g..."
...Furthermore, this pattern has also been observed Cell Stem Cell 8, May 6, 2011 ª2011 Elsevier Inc. 491 with spheres that arise from isolated mammary populations, termed mammospheres (Stingl, 2009)....
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Cites background from "Detection and analysis of mammary g..."
...The identification of normal adult stem cells in the mouse mammary gland (reviewed in Stingl (2009)) and of tumourigenic cells within human breast tumours bymeans of cell surface markers and transplantation assays in immunodeficient mice has fuelled the concept that cancers are initiated and…...
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...…human breast tumours bymeans of cell surface markers and transplantation assays in immunodeficient mice has fuelled the concept that cancers are initiated and maintained by a population of tumour cells with stem celllike features (i.e. ‘cancer stem cells’) (Stingl, 2009; Al-Hajj et al., 2003)....
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References
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"Detection and analysis of mammary g..." refers background in this paper
...For example, assuming that in vivo engraftment in the original Al-Hajj manuscript followed single-hit engraftment kinetics, the frequency of these tumour-initiating cells was <1% within the EpCAM+CD44+CD24−/low subpopulation [74]....
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...In 2003 a manuscript was published which demonstrated that human breast tumours have a cancer stem cell (CSC) component and these cells have an EpCAM+CD44+CD24−/low phenotype, at least in eight of the nine tumour samples examined [74]....
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8,999 citations
6,709 citations
"Detection and analysis of mammary g..." refers background in this paper
...Studies in the haematopoietic field have demonstrated that haematopoietic stem cells (HSCs) are the likely target for oncogenic mutation in human acute myeloid leukaemia (AML), since both the normal HSCs and the AML-CSCs share the same CD34+CD38− phenotype [79]....
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...Committed progenitors can also function as the cell of origin in human acute promyelocytic leukaemia and mouse acute myelogenous leukaemia [79,87,88]....
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