Detection of a New Pyrethroid Resistance Mutation (V410L) in the Sodium Channel of Aedes Aegypti: A Potential Challenge for Mosquito Control
Khalid Haddi,Hudson V. V. Tomé,Yuzhe Du,Wilson R. Valbon,Yoshiko Nomura,Gustavo Ferreira Martins,Ke Dong,Eugênio E. Oliveira +7 more
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TLDR
The V410L mutation drastically reduced the sensitivity of mosquito sodium channels expressed in Xenopus oocytes to both type I and type II pyrethroids and presents a serious challenge for the control of A. aegypti in Brazil.Abstract:
The yellow fever mosquito, Aedes aegypti, particularly in Neotropical regions, is the principal vector of dengue, yellow fever, Zika and Chikungunya viruses. Pyrethroids remain one of the most used insecticides to control Aedes mosquitoes, despite the development of pyrethroid resistance in many mosquito populations worldwide. Here, we report a Brazilian strain of A. aegypti with high levels (approximately 100-60,000 fold) of resistance to both type I and type II pyrethroids. We detected two mutations (V410L and F1534C) in the sodium channel from this resistant strain. This study is the first report of the V410L mutation in mosquitoes. Alone or in combination with the F1534C mutation, the V410L mutation drastically reduced the sensitivity of mosquito sodium channels expressed in Xenopus oocytes to both type I and type II pyrethroids. The V410L mutation presents a serious challenge for the control of A. aegypti and will compromise the use of pyrethroids for the control of A. aegypti in Brazil; therefore, early monitoring of the frequency of the V410L mutation will be a key resistance management strategy to preserve the effectiveness of pyrethroid insecticides.read more
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Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
Karla Saavedra-Rodriguez,Farah Vera Maloof,Corey L. Campbell,Julian E. Garcia-Rejon,Audrey Lenhart,Patricia R. Penilla,Américo D. Rodríguez,Arturo Acero Sandoval,Adriana E. Flores,Gustavo Ponce,Saul Lozano,William C. Black +11 more
TL;DR: A novel replacement V410L was identified in Brazil and its effect on vgsc was confirmed by electrophysiology, and it was screened in 25 Ae.
Journal ArticleDOI
Distribution of insecticide resistance and mechanisms involved in the arbovirus vector Aedes aegypti in Laos and implication for vector control.
Sébastien Marcombe,Bénédicte Fustec,Julien Cattel,Somesanith Chonephetsarath,Phoutmany Thammavong,Nothasin Phommavanh,Jean-Philippe David,Vincent Corbel,Ian W. Sutherland,Jeffrey C. Hertz,Paul T. Brey +10 more
TL;DR: The presence of high levels of insecticide resistance in the main arbovirus vector in Laos is worrying and may have important implications for dengue vector control in the country.
Journal ArticleDOI
Quantification of permethrin resistance and kdr alleles in Florida strains of Aedes aegypti (L.) and Aedes albopictus (Skuse)
Alden S. Estep,Neil D. Sanscrainte,Christy M. Waits,Sarah J. Bernard,Aaron M. Lloyd,Keira J. Lucas,Eva A. Buckner,Rajeev Vaidyanathan,Rachel Morreale,Lisa A. Conti,James J. Becnel +10 more
TL;DR: This study provides a statewide examination of pyrethroid resistance, and demonstrates that permethrin resistance and the genetic markers for resistance are widely present in FL Ae.
Journal ArticleDOI
Larvicidal effect of essential oils from Brazilian cultivars of guava on Aedes aegypti L.
Luiza Alves Mendes,Gustavo Ferreira Martins,Wilson R. Valbon,Tércio da Silva de Souza,Luciano Menini,Adésio Ferreira,Marcia Flores da Silva Ferreira +6 more
TL;DR: The chromatographic profile of the essential oils evidenced mainly sesquiterpenes; hence, this group of compounds may be responsible for the larvicidal effect of A. aegypti, constituting a larvicide alternative.
Journal ArticleDOI
Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti
Mengli Chen,Mengli Chen,Yuzhe Du,Shaoying Wu,Yoshiko Nomura,Guonian Zhu,Boris S. Zhorov,Boris S. Zhorov,Ke Dong +8 more
TL;DR: It is proposed that mutation F1534C first emerged in response to DDT/pyrethroids providing a platform for subsequent selection of mutations V1016I and T1520I that confer greater and broader spectrum of pyrethroid resistance.
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