Determination and characterization of a cannabinoid receptor in rat brain.
Citations
5,283 citations
2,764 citations
2,619 citations
Cites background from "Determination and characterization ..."
...Less lipophilic than THC, [(3)H]CP55940 has allowed the discovery and characterization of the CB1 cannabinoid receptor (Devane et al., 1988), and it is still the most used radiolabeled cannabinoid ligand....
[...]
...Less lipophilic than THC, [3H]CP55940 has allowed the discovery and characterization of the CB1 cannabinoid receptor (Devane et al., 1988), and it is still the most used radiolabeled cannabinoid ligand....
[...]
2,179 citations
2,070 citations
References
225,085 citations
"Determination and characterization ..." refers methods in this paper
...Protein values were determined by the method of Bradford ( 17 ) using...
[...]
8,717 citations
574 citations
"Determination and characterization ..." refers background in this paper
...The effects of Mgi to increase the affinity of agonist ligands for receptors associated with aden- ylate cyclase have been discussed by Maguire (25)....
[...]
...It is believed that the G protein possesses at least one site for Mgi (23, 24)....
[...]
...of Gpp(NH)p would be the prevalent state concurrent with adenylate cyclase regulation (23, 24)....
[...]
...Our current understanding of the influence of G proteins on agonist-receptor interactions has been reviewed by Birnbaumer and colleagues (23) and Casey and Gilman (24)....
[...]
...A role for this divalent cation has been shown for the dissociation of GDP in the presence of the receptor-hormone complex, in addition to other functions associated with a site having a much higher affinity for Mgi (23, 24)....
[...]
530 citations
469 citations