Determination of Hydrogen Peroxide and Silver Ions Using G-Quadruplex/Hemin Catalyzed Luminol Chemiluminescence
About: This article is published in Analytical Letters.The article was published on 2021-11-02 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Hydrogen peroxide & Hemin.
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TL;DR: In this article , four bis-acridinium esters were synthesized using common methods, and their chemiluminescence properties were investigated at pH 7−10.
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TL;DR: Taking into account the advantages of ultra-small size, good stability, and high biocompatibility in aqueous solutions, Cu NCs are expected to have potential applications in biotechnology and clinical diagnosis as enzymatic mimics.
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TL;DR: A simple and cost-effective sensor could be successfully applied for simultaneously detecting Pb(2+), Ag(+), and Hg(2+) in calf serum and lake water.
Abstract: An unlabeled immobilized DNA-based sensor was reported for simultaneous detection of Pb2+, Ag+, and Hg2+ by electrochemical impedance spectroscopy (EIS) with [Fe(CN)6]4–/3– as redox probe, which consisted of three interaction sections: Pb2+ interaction with G-rich DNA strands to form G-quadruplex, Ag+ interaction with C–C mismatch to form C–Ag+–C complex, and Hg2+ interaction with T–T mismatch to form T–Hg2+–T complex. Circular dichroism (CD) and UV–vis spectra indicated that the interactions between DNA and Pb2+, Ag+, or Hg2+ occurred. Upon DNA interaction with Pb2+, Ag+, and Hg2+, respectively, a decreased charge transfer resistance (RCT) was obtained. Taking advantage of the RCT difference (ΔRCT), Pb2+, Ag+, and Hg2+ were selectively detected with the detection limit of 10 pM, 10 nM, and 0.1 nM, respectively. To simultaneously (or parallel) detect the three metal ions coexisting in a sample, EDTA was applied to mask Pb2+ and Hg2+ for detecting Ag+; cysteine was applied to mask Ag+ and Hg2+ for detectin...
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TL;DR: A new bio-bar-code-based split-type photoelectrochemical immunoassay was designed for sensitive detection of prostate-specific antigen (PSA), coupling rolling circle amplification (RCA) with enzymatic biocatalytic precipitation and showed good reproducibility, high specificity and accuracy matched well with commercial PSA ELISA kits for real sample analysis.
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TL;DR: A simple visual method for Ag(+)- or Cys-detection was developed, which allows simple detection of aqueous Ag(+) with a detection limit of 64 nM and a linear range of 50-3000 nM.
Abstract: Some G-quadruplex−hemin complexes are DNAzyme peroxidases that efficiently catalyze H2O2-mediated reactions, such as the oxidation of ABTS (2,2′-azinobis(3-ethylbenzothiozoline)-6-sulfonic acid) by H2O2. Since Ag+ chelates guanine bases at the binding sites are involved in G-quadruplex formation, the presence of Ag+ may disrupt these structures and inhibit the peroxidase activity of G-quadruplex−hemin DNAzymes. On the basis of this principle, a highly sensitive and selective Ag+-detection method was developed. The method allows simple detection of aqueous Ag+ with a detection limit of 64 nM and a linear range of 50−3000 nM. Cysteine (Cys) is a strong Ag+-binder and competes with quadruplex-forming G-rich oligonucleotides for Ag+-binding, promoting the reformation of G-quadruplexes and increasing their peroxidase activity. Therefore, the Ag+-sensing system was also developed as a Cys-sensing system. This “turn-on” process allowed the detection of Cys at concentrations as low as 50 nM using a simple colorim...
186 citations
TL;DR: It was envisioned that catalyst-functionalized MOFs for chemiluminescence sensing would have promising applications in green, selective, and sensitive detection of target analytes in the future.
Abstract: Novel metal–organic frameworks (MOFs) based solid catalysts have been synthesized by encapsulating Hemin into the HKUST-1 MOF materials. These have been first applied in the chemiluminescence field with outstanding performance. The functionalized MOFs not only maintain an excellent catalytic activity inheriting from Hemin but also can be cyclically utilized as solid mimic peroxidases in the neutral condition. The synthesized Hemin@HKUST-1 composites have been used to develop practical sensors for H2O2 and glucose with wide response ranges and low detection limits. It was envisioned that catalyst-functionalized MOFs for chemiluminescence sensing would have promising applications in green, selective, and sensitive detection of target analytes in the future.
166 citations