Journal ArticleDOI
Determination of salicylic acid and two metabolites in plasma and urine using fluorimetry for directly measuring salicyluric acid.
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TLDR
An improved method has been developed for the measurement of salicylic acid and salicyluric acid in blood plasma and for these two substances and Salicyl glycuronates in urine and a higher value than previously reported has been found.Abstract:
An improved method has been developed for the measurement of salicylic acid and salicyluric acid in blood plasma and for these two substances and salicyl glycuronates in urine. Older methods measured salicyluric acid by the different extraction efficiencies of two solvents and the weaker color formation of salicyluric acid with ferric nitrate. This method measures salicyluric acid more specifically by means of its marked fluorescence at p H 10. A low concentration of a fluorescent substance, probably salicyluric acid, which has not been reported previously was found in dog plasma following large doses of sodium salicylate. The rate of hydrolysis of salicyluric acid by concentrated hydrochloric acid, an important factor in the calculation of the salicyl glycuronate fraction in this and former methods, has been re-examined and a higher value than previously reported has been found. An explanation of this difference is suggested. A synthetic sample of the glycuronate of salicylic acid coupled through the phenolic hydroxyl group, which has not been isolated from urine in pure form, has been tested for reactivity in the method.read more
Citations
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Potentially harmful drug-drug interactions in the elderly: a review.
Lisa E. Hines,John E. Murphy +1 more
TL;DR: Several population-based studies have reported significant harm associated drug interactions in elderly patients and increased awareness and interventions aimed at reducing exposure and minimizing the risks associated with potentially harmful drug combinations are needed.
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Inappropriate prescribing: a systematic overview of published assessment tools.
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Journal ArticleDOI
Salicylate and salicyl conjugates: fluorimetric estimation, biosynthesis and renal excretion in man.
David Schachter,James G. Manis +1 more
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Assessment of potential drug–drug interactions with a prescription claims database
Daniel C. Malone,David S. Hutchins,Heather Haupert,Philip D. Hansten,Babette S. Duncan,Robin C. Van Bergen,Steve L. Solomon,Richard B. Lipton +7 more
TL;DR: Analysis of prescription claims data from a major PBM found that 374,000 of 46 million participants in a PBM had been exposed to a potential DDI of clinical importance.
Journal ArticleDOI
Pharmacist workload and pharmacy characteristics associated with the dispensing of potentially clinically important drug-drug interactions
Daniel C. Malone,Jacob Abarca,Grant H. Skrepnek,John E. Murphy,Edward P. Armstrong,Amy J. Grizzle,Rick A. Rehfeld,Raymond L. Woosley +7 more
TL;DR: There was an increase in the risk of dispensing a potential DDI with higher pharmacist and pharmacy workload, use of specific automation, and dispensing software programs providing alerts and clinical information.
References
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Journal Article
The determination of salicylic acid in plasma
TL;DR: In this paper, the salicylic acid is separated from plasma by extraction with ethylene dichloride from an acid medium and then returned as the colored iron complex to an aqueous phase and determined colorimetrically.
Journal Article
Studies on the pharmacology of salicylates
Smith Pk,Gleason Hl +1 more
TL;DR: The administration of sodium bicarbonate to patients receiving sodium salicylate results in an increased excretion of free salicYLate, with the renal clearances of free Salicylates increasing rapidly above pH 7 in the urine.
Journal ArticleDOI
Fluorophotometric method for the estimation of salicylate in blood.
Journal Article
The metabolism of c14 carboxyl salicylic acid in the dog and in man
TL;DR: Two conjugates of salicylic acid with glycuronic acid have been identified in human urine, one of which retains a free saucyl hydroxyl group, and one conjugate of salicylate with glyCuronic acid has been found in dog urine.