Journal ArticleDOI
Determination of urinary N-acetylneuraminic acid for early diagnosis of lung cancer by a boric acid covalently functionalized lanthanide MOFs and its intelligent visual molecular robot application
Yu Zhang,Haifeng Lu,Bing Yan +2 more
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TLDR
In this article, a boric acid covalently functionalized lanthanide MOF (Ln-MOF) sensor was constructed for the first time to monitor of urinary N-acetylneuraminic acid (NANA) to early diagnose of lung cancer, NANA can be used as biomarker.Abstract:
In this work, a boric acid covalently functionalized lanthanide MOF (Ln-MOF) sensor was constructed for the first time to monitor of urinary N-acetylneuraminic acid (NANA) to early diagnose of lung cancer, NANA can be used as biomarker of lung cancer. Considering that the specific binding affinity between boronic acid group and cis-diol can probably cause special influence towards the fluorescence of Ln-MOF, a boric-acid-functionalized Ln-MOF (B-EuMOF) sensor was first designed by covalent modification, which is proved to be an effective ratiometric fluorescent sensor of NANA, a urinary biomarker of lung cancer containing cis-diol. This designed NANA sensor shows special enrichment capacity, high selectivity and sensitivity, fast response, excellent reusability and more important, the ratiometric sensing result can be clearly distinguished by naked eye. Based on the luminescent sensing property of B-EuMOF towards NANA and the capture function of boric acid group, a molecular robot system which can monitor lung cancer at early stage is constructed. In this molecular robot system, boronic acid group serves as the actuator using ‘functional-hand’ to grasp NANA for the molecular robots. The fluorescence of B-EuMOF (I470 nm/I614 nm) act as the sensor of the molecular robots. And the processor is constructed by combinational logic gates (INHIBIT and AND) which can control the molecular robots by logical operation of fluorescence response of B-EuMOF towards NANA. This work proposes first example of Ln-MOFs based molecular robot and what’s more, paves new way for the combination of fluorescent sensor and intelligent molecular devices.read more
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Journal ArticleDOI
Luminescent Lanthanide Metal Organic Frameworks (LnMOFs): A Versatile Platform towards Organomolecule Sensing
TL;DR: Lanthanide metal-organic frameworks (LnMOFs) have shown remarkable promise for detecting organomolecules with high accuracy because of their easy tunability, functionality, and design ability as discussed by the authors .
Journal ArticleDOI
A new three-dimensional zinc(II) metal-organic framework as a fluorescence sensor for sensing the biomarker 3-nitrotyrosine.
TL;DR: In this paper , a 3D zinc-based metal-organic framework (Zn-MOF) was used as a highly efficient fluorescence sensing material to provide a direct and low-cost method for the rapid detection of 3-NT and shows high sensitivity with a KSV value of 6.596 × 104 M-1, excellent selectivity, high anti-interference ability and good recyclability.
Journal ArticleDOI
Ratiometric fluorescence sensing with logical operation: Theory, design and applications.
Lijun Liu,Lu Ga,Jun Ai +2 more
TL;DR: In this article , the basic principles of various logic functions implemented in ratiometric fluorescence detection are discussed in the context of sensing mechanisms, and the strategies for constructing logic systems in different ratiometric fluorescence sensing application areas are summarized.
Journal ArticleDOI
A 2-in-1 multi-functionalized sensor for efficient epinephrine detection based on cucurbit[7]uril functionalized lanthanide metal-organic framework and its intelligent application on molecular robot
Yu Zhang,Binghai Yan +1 more
TL;DR: In this paper , the authors developed a multifunctional sensor with both enrichment ability and sensing functions for the identification of disease analyte in human body requires facile sensing method with high reliability and seletivity.
References
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The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
Journal ArticleDOI
From fundamentals to applications: a toolbox for robust and multifunctional MOF materials.
TL;DR: This review provides insight into both existing structures and emerging aspects of MOFs, as well as emerging trends of MOF development.
Journal ArticleDOI
Molecular robots guided by prescriptive landscapes
Kyle Lund,Anthony J. Manzo,Dabby Nadine L,Nicole Michelotti,Alexander Johnson-Buck,Jeanette Nangreave,Steven Taylor,Renjun Pei,Milan N. Stojanovic,Nils G. Walter,Erik Winfree,Hao Yan +11 more
TL;DR: It is demonstrated that previously developed random walkers show elementary robotic behaviour when interacting with a precisely defined environment and single-molecule microscopy observations confirm that such walkers achieve directional movement by sensing and modifying tracks of substrate molecules laid out on a two-dimensional DNA origami landscape.
Journal ArticleDOI
Metal-organic frameworks for luminescence thermometry.
TL;DR: Recent progress made in luminescent MOF thermometers are summarized, with particular emphasis on the dual-emitting MOFs that effectively illustrate the self-referencing temperature measurement based on the intensity ratios of two separate transitions.
Journal ArticleDOI
A flexible Eu(III)-based metal–organic framework: turn-off luminescent sensor for the detection of Fe(III) and picric acid
TL;DR: The potential of 1b for Fe(3+) ions and PA sensing was studied in DMF through the luminescence quenching experiments, which show 1b is a potential turn-off luminescent sensory material for the selective detection of Fe( 3+) ion and PA with detection limits of around 10(-7) M for both of them.