Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
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Cites background from "Deterministically patterned biomime..."
...Using such a manufacturing principle, hydrogel objects with complex 3D architecture andmultiplexedmaterials may be generated with high spatial resolution (100, 117)....
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...For example, almost all organs in the human body contain repeating building units that assemble into distinctive compartments and interfaces [for example, the myocardium, endocardium, and pericardium in the heart (98, 99) and the lobules constituting the liver (99, 100)]....
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References
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"Deterministically patterned biomime..." refers methods in this paper
...GelMA was synthesized according to previously published procedures (45)....
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1,653 citations
"Deterministically patterned biomime..." refers background or methods in this paper
..., HPCs and HLCs, respectively, have demonstrated their potentials in organizing into vascularized liver buds (11, 13) and in the construction of in vitro models with simple geometry (10, 12, 14)....
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...potentials in forming functional vasculatures as shown and discussed in previous studies (11, 13, 31)....
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"Deterministically patterned biomime..." refers background or result in this paper
...The greater HPC aggregate size observed in this 3D triculture model further supports the beneficial effects from supporting cells as widely reported in 2D coculture models (14, 42)....
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...The significant induction by rifampicin of CYP3A4, CYP2C9, and CYP2C19 expression levels shows that hiPSC-HPCs after 7 d in 3D triculture are able to respond positively to rifampicin as reported for primary hepatocytes (42), thus potentially improving the metabolism and clearance of the drug....
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...4 D, iv), which was previously reported to be induced by rifampicin in adult hepatocytes (41, 42)....
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