Open AccessJournal Article
Development and characterization of TPGS modified proniosomes of docetaxel
Reads0
Chats0
TLDR
Results indicate the oral delivery system of DTX-TPGS-PN was successfully built with good properties, exhibiting spherical morphology and biphasic release process that a low burst effect within the first 0.5 hour and a relative-sustained release for the next several hours in PBS.Abstract:
A novel oral delivery system that TPGS modified docetaxel proniosomes, DTX-TPGS-PN, was developed and the characterization after hydration was observed. Firstly, Doce-TPGS-PN was optimized by investing the factors, including the type of surfactant, methods of adding TPGS, content of TPGS and the molar ratio of span40/cholesterol, which may affecting the particle size, encapsulation efficiency and instantaneous release of drug in the formulation. Then, the morphology, particle size, Zeta potential, encapsulation efficiency and in vitro release of the formulation were evaluated. The result showed that hydrated nanoparticles of DTX-TPGS-PNs were (93 ± 6.5) nm in size,(-83.95 ± 3.69) mV in zeta potential, (97.31 ± 0.60)% in encapsulation efficiency, exhibiting spherical morphology and biphasic release process that a low burst effect within the first 0.5 hour and a relative-sustained release for the next several hours in PBS. These results indicate the oral delivery system of DTX-TPGS-PN was successfully built with good properties.read more
Citations
More filters
Journal ArticleDOI
Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends
Muhammad Farhan Sohail,Mubashar Rehman,Hafiz Shoaib Sarwar,Sara Naveed,Omer Salman,Nadeem Irfan Bukhari,Irshad Hussain,Thomas J. Webster,Gul Shahnaz +8 more
TL;DR: The present article comprehensively reviews the research efforts made so far in designing various advancements in the oral delivery of Docetaxel and presents key issues such as safety of nanomaterials, regulatory approval and future trends in nanomedicine research.
Related Papers (5)
Central composite design-based optimization of lopinavir vitamin E-TPGS micelle: In vitro characterization and in vivo pharmacokinetic study.
In vitro and in vivo studies on vitamin E TPGS-emulsified poly(d,l-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation
Khin Yin Win,Si-Shen Feng +1 more