Journal Article•
Development of a Lipid Particle for β-Carotene Encapsulation Using a Blend of Tristearin and Sunflower Oil: Choice of Lipid Matrix and Evaluation of Shelf Life of Dispersions
09 Sep 2013-Food Technology and Biotechnology (University of Zagreb, Faculty of Food Technology and Biotechnology (Sveuciliste u Zagrebu, Prehrambeno-Biotechnolosk i Fakultet))-Vol. 51, Iss: 3, pp 383-391
TL;DR: In this article, the authors choose a suitable lipid matrix to produce solid lipid particles, which would be used to encapsulate b-carotene, and evaluate the capacity of dispersions to protect the incorporated carotenoid.
Abstract: Summary Solid lipid particles are colloidal carriers that have been studied for almost 20 years in the pharmaceutical field and recently have been investigated by food researchers due to their capacity to enhance the incorporation of lipophilic bioactives and their bioavailability in aqueous formulations. The aims of this study are to choose a suitable lipid matrix to produce solid lipid particles, which would be used to encapsulate b-carotene, and to evaluate the capacity of dispersions to protect the incorporated carotenoid. Bulk lipid mixtures of tristearin and sunflower oil were analysed by differential scanning calorimetry and wide angle X-ray diffraction, and the mixture with the highest degree of structural disorganisation was chosen. b-Carotene was then encapsulated in solid lipid particles produced with this mixture, composed of 70 % tristearin and 30 % sunflower oil (6 % total lipid) and stabilised with hydrogenated soy lecithin and Tween 80 (3 % total surfactant) by hot pressure homogenisation. Two types of particles were produced, using one or two passages in the homogenisation step. Average particle size, zeta potential, thermal behaviour, crystallinity and b-carotene concentration were monitored over 4 months of storage (under refrigerated conditions). The results showed minor differences between the systems in terms of size distribution, although the particles produced with one passage through the homogeniser were slightly more efficient at protecting the b-carotene from degradation and also suffered few microstructural alterations after 4 months.
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Cites background from "Development of a Lipid Particle for..."
...The need for coencapsulation with an antioxidant to protect encapsulated beta-carotene has been also realized in other studies (Hentschel et al., 2008; Tikekar et al., 2011; Gomes et al., 2013)....
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TL;DR: Nanostructured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications.
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