Development of Fibroblast Activation Protein–Targeted Radiotracers with Improved Tumor Retention
Citations
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Cites background or methods from "Development of Fibroblast Activatio..."
...successfully increased FAP binding and improved pharmacokinetics by chemical modification of the FAPI probes (10)....
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...FAPI compounds, such as FAPI-21 or -46, which exhibit improved tumor retention, should be used in future studies (10)....
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135 citations
114 citations
Cites methods from "Development of Fibroblast Activatio..."
...This was done either by alteration of the lipophilicity by variations of the linker region mainly by bicyclic analogues of the original piperazine moiety or by modification of the chemistry used for DOTA/linker-attachment at the quinoline moiety (Loktev et al. 2019)....
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References
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"Development of Fibroblast Activatio..." refers background in this paper
...All FAPI derivatives up to FAPI-36 were synthesized as previously described (10,11), whereas the attachment of the bicyclic diamines required higher temperatures and longer reaction times....
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...In our previous work, we presented the development of several quinoline-based theranostic radiotracers, which were successfully used for tumor imaging of a multitude of different cancers, including pancreas, breast, and colon carcinoma, as well as high-grade glioblastoma (10,11)....
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406 citations
"Development of Fibroblast Activatio..." refers result in this paper
...A comparison with the commonly used radiotracer 18FFDG revealed equal or improved tumor-to-background contrast ratios for FAPI-04 in 6 cancer patients (12)....
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395 citations
"Development of Fibroblast Activatio..." refers background in this paper
...All FAPI derivatives up to FAPI-36 were synthesized as previously described (10,11), whereas the attachment of the bicyclic diamines required higher temperatures and longer reaction times....
[...]
...In our previous work, we presented the development of several quinoline-based theranostic radiotracers, which were successfully used for tumor imaging of a multitude of different cancers, including pancreas, breast, and colon carcinoma, as well as high-grade glioblastoma (10,11)....
[...]