Journal ArticleDOI
Development of mebendazole loaded nanostructured lipid carriers for lymphatic targeting: Optimization, characterization, in-vitro and in-vivo evaluation
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TLDR
MBZ loaded NLCs could be regarded as a potential carrier for sustained delivery of MBZ and efficient carrier for lymphatic targeting and high drug entrapment efficiency and bioavailability.Abstract:
The basic objective of research work was to develop, optimize and evaluate MBZ loaded NLCs to overcome the issues of poor solubility and bioavailability of the drug. The nanoformulation was prepare...read more
Citations
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Recent advances in lymphatic targeted drug delivery system for tumor metastasis
TL;DR: Novel and effective lymphatic targeted drug delivery systems have been explored to improve the specificity of anticancer drugs to tumor cells in lymph nodes and recent advances in the development of lymphatics targeted carriers are discussed.
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Enhanced Lymphatic Delivery of Methotrexate Using W/O/W Nanoemulsion: In Vitro Characterization and Pharmacokinetic Study.
TL;DR: The prepared nanoemulsion showed significant increases in maximum plasma concentration, area under the plasma concentration-time curve, half-life, oral bioavailability, and lymphatic targeting efficiency in both oral and intravenous administration.
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Nanocarriers based oral lymphatic drug targeting: Strategic bioavailability enhancement approaches
TL;DR: Various strategies to enhance drug bioavailability through lymphatic targeting are discussed, which can improve the treatment efficacy, survival, and life expectancy of the patient.
Journal ArticleDOI
Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection
Mohammed A.S. Abourehab,Ahmed Khames,Samar Genedy,Shahin Mostafa,Mohammad A. Khaleel,Mahmoud M Omar,Amani M. El Sisi +6 more
TL;DR: In this paper, the authors formulated and optimized sesame oil-based NIC-nanostructured lipid carriers (NIC-NLCs) for intranasal (IN) delivery with expected synergistic and augmented neuroprotective properties.
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Quality by design (QbD)–based fabrication of atazanavir-loaded nanostructured lipid carriers for lymph targeting: bioavailability enhancement using chylomicron flow block model and toxicity studies
TL;DR: A safe and promising drug targeting system was successfully developed to improve bioavailability and avoiding first-pass effect ensures to circumvent the acute-toxicity of liver.
References
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Journal ArticleDOI
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
TL;DR: From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).
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LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors.
Guopei Luo,Xianjun Yu,Chen Jin,Feng Yang,Deliang Fu,Jiang Long,Jin Xu,Changyou Zhan,Weiyue Lu +8 more
TL;DR: This study indicates that LyP-1-NP is a promising carrier for target-specific drug delivery to lymphatic metastatic tumors.
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Solid lipid nanoparticles (SLN) of Efavirenz as lymph targeting drug delivery system: Elucidation of mechanism of uptake using chylomicron flow blocking approach.
TL;DR: The results from lymphatic transport and tissue distribution study indicate that a significant part of the EFV had by-passed portal system and was recovered in the lymph via chylomicron uptake mechanism, indicating that major amount of EFV bypasses the liver and thereby, enhances the oral bioavailability of theEFV.
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Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: In vitro and in vivo evaluation.
Spandana Inugala,Basanth Babu Eedara,Sharath Sunkavalli,Rajeshri Dhurke,Prabhakar Kandadi,Raju Jukanti,Suresh Bandari +6 more
TL;DR: Investigation of solid self-nanoemulsifying drug delivery system (S-SNEDDS) composed of Capmul MCM C8, Tween 80 and Transcutol P found presence of drug in non-crystalline amorphous state without any significant interaction of drug with the components of S- SNEDDS.
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Lymphatic targeting of zidovudine using surface-engineered liposomes.
TL;DR: The SE liposomes appeared to be promising novel vesicular system for enhanced targeting of ZDV to lymphatics, in AIDS chemotherapy.